Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2015 Jun:118:39-45.
doi: 10.1016/j.antiviral.2015.03.007. Epub 2015 Mar 19.

Targeting dengue virus NS4B protein for drug discovery

Xuping Xie  1 , Jing Zou  2 , Qing-Yin Wang  3 , Pei-Yong Shi  4
Affiliations
Review

Targeting dengue virus NS4B protein for drug discovery

Xuping Xie et al. Antiviral Res. 2015 Jun.

Abstract

The flavivirus nonstructural 4B protein (NS4B) has recently emerged as a valid antiviral target for drug discovery. Here we review (i) the current understanding of the structure and function of DENV NS4B, (ii) the approaches that have been taken to identify NS4B inhibitors, and (iii) the known inhibitors of flavivirus NS4B protein. This article forms part of a symposium in Antiviral Research on flavivirus drug discovery.

Keywords: Antivirals; Dengue; Flavivirus; NS4B; Nonstructural protein 4B.

PubMed Disclaimer

Publication types

MeSH terms

LinkOut - more resources