Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2016 Mar:157:3-6.
doi: 10.1016/j.jsbmb.2015.03.004. Epub 2015 Mar 19.

Historical overview of nuclear receptors

Jan-Ake Gustafsson  1
Affiliations
Review

Historical overview of nuclear receptors

Jan-Ake Gustafsson. J Steroid Biochem Mol Biol. 2016 Mar.

Abstract

This review summarizes the birth of the field of nuclear receptors, from Jensen's discovery of estrogen receptor alpha, Gustafsson's discovery of the three-domain structure of the glucocorticoid receptor, the discovery of the glucocorticoid response element and the first partial cloning of the glucocorticoid receptor. Furthermore the discovery of the novel receptors called orphan receptors is described.

Keywords: Domain structure; Orphan receptor; Steroid response element.

PubMed Disclaimer

LinkOut - more resources