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Comparative Study
. 1985 Apr 1;148(1):1-5.
doi: 10.1111/j.1432-1033.1985.tb08798.x.

Synthetic and natural Escherichia coli free lipid A express identical endotoxic activities

C Galanos, O Lüderitz, E T Rietschel, O Westphal, H Brade, L Brade, M Freudenberg, U Schade, M Imoto, H Yoshimura, et al.
Free article
Comparative Study

Synthetic and natural Escherichia coli free lipid A express identical endotoxic activities

C Galanos et al. Eur J Biochem. .
Free article

Abstract

The recently chemically synthesized Escherichia coli lipid A and the natural free lipid A of E. coli were compared with respect to their endotoxic activities in the following test systems: lethal toxicity, pyrogenicity, local Shwartzman reactivity, Limulus amoebocyte lysate gelation capacity, tumour necrotizing activity, B cell mitogenicity, induction of prostaglandin synthesis in macrophages, and antigenic specificity. It was found that synthetic and natural free lipid A exhibit identical activities and are indistinguishable in all tests.

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