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. 1985 Jan 2;107(2):279-81.
doi: 10.1016/0014-2999(85)90071-8.

Inhibition of IgE-mediated mast cell degranulation by sulphasalazine

K E Barrett, T L Tashof, D D Metcalfe

Inhibition of IgE-mediated mast cell degranulation by sulphasalazine

K E Barrett et al. Eur J Pharmacol. .

Abstract

The effect of sulphasalazine on two mast cell populations and human peripheral leukocytes is reported. Sulphasalazine inhibited histamine release from mouse and rat mast cells, but it caused a potentiation of secretion in human peripheral leukocytes. The drug alone did not induce histamine release when administered without an anaphylactic stimulus. The results are discussed in terms of a possible mode of action of sulphasalazine in the treatment of inflammatory bowel disease.

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