doi: 10.1084/jem.161.4.785.
A subset of Ly-1 inducer T cell clones activates B cell proliferation but directly inhibits subsequent IgG secretion
- PMID: 2580039
- PMCID: PMC2189061
- DOI: 10.1084/jem.161.4.785
Item in Clipboard
A subset of Ly-1 inducer T cell clones activates B cell proliferation but directly inhibits subsequent IgG secretion
J Exp Med.
.
Abstract
We find that a fraction of Ly-1+2- inducer T cell clones inhibits differentiation of memory B cells into IgG-secreting plaque-forming cells. Inhibition of secondary antibody responses was not the result of induction of Ly-2+ T suppressors. Instead, inducer cells directly inactivated B cells, requiring an antigen bridge as well as identity at the major histocompatibility complex (I-A) locus. The interaction between the inducer T cell clone and hapten-specific B memory cells results in an early proliferative response and subsequent failure of B cells to secrete antibody in response to T helper cell signals. Possible mechanisms for this novel type of B cell inactivation are explored.
Similar articles
-
T cell regulation of antibody responses: an I-A-specific, autoreactive T cell collaborates with antigen-specific helper T cells to promote IgG responses.J Immunol. 1985 Feb;134(2):691-4. J Immunol. 1985. PMID: 2578161
-
Activation of B cells by autoreactive T cells: cloned autoreactive T cells activate B cells by two distinct pathways.J Immunol. 1984 Jul;133(1):78-85. J Immunol. 1984. PMID: 6202794
-
Establishment of three PPD-reactive helper T cell clones with distinct functions in B cell activation.J Immunol. 1984 Aug;133(2):629-35. J Immunol. 1984. PMID: 6234353
-
The complexity of structures involved in T-cell activation.Annu Rev Immunol. 1983;1:465-98. doi: 10.1146/annurev.iy.01.040183.002341. Annu Rev Immunol. 1983. PMID: 6085787 Review. No abstract available.
-
Regulation of the immune response T-cell interactions.CRC Crit Rev Immunol. 1982 Feb;3(3):209-61. CRC Crit Rev Immunol. 1982. PMID: 6176399 Review. No abstract available.
Cited by
-
Alloreactivity of an OVA-specific T-cell clone. I. Stimulation by class II MHC and novel non-MHC B-cell determinants.Immunogenetics. 1987;26(4-5):193-203. doi: 10.1007/BF00346512. Immunogenetics. 1987. PMID: 3498687
-
Conventional antigen and superantigen may be coupled to distinct and cooperative T-cell activation pathways.Proc Natl Acad Sci U S A. 1991 Oct 1;88(19):8705-9. doi: 10.1073/pnas.88.19.8705. Proc Natl Acad Sci U S A. 1991. PMID: 1681539 Free PMC article.
-
Immunological function of the blood-cerebrospinal fluid barrier.Proc Natl Acad Sci U S A. 1989 Mar;86(5):1684-8. doi: 10.1073/pnas.86.5.1684. Proc Natl Acad Sci U S A. 1989. PMID: 2784211 Free PMC article.
-
Definition of a specific interaction between the early T lymphocyte activation 1 (Eta-1) protein and murine macrophages in vitro and its effect upon macrophages in vivo.J Exp Med. 1990 Jun 1;171(6):1931-42. doi: 10.1084/jem.171.6.1931. J Exp Med. 1990. PMID: 2351930 Free PMC article.
-
Differential induction of interferon gamma gene expression after activation of CD4+ T cells by conventional antigen and Mls superantigen.Proc Natl Acad Sci U S A. 1991 Apr 1;88(7):2736-9. doi: 10.1073/pnas.88.7.2736. Proc Natl Acad Sci U S A. 1991. PMID: 1707172 Free PMC article.
