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. 2015 Jun;23(6):321-3.
doi: 10.1016/j.tim.2015.02.013. Epub 2015 Mar 21.

Detecting virulence and drug-resistance mycobacterial phenotypes in vivo

Graham S Timmins  1
Affiliations

Detecting virulence and drug-resistance mycobacterial phenotypes in vivo

Graham S Timmins. Trends Microbiol. 2015 Jun.

Abstract

Bacterial phenotypes are predominantly studied in culture because detection of their specific metabolic pathways in the host is challenging. Development of stable-isotope breath tests, allowing in situ phenotype analyses, may endow diagnostics with new modalities based upon direct monitoring of in vivo microbial metabolism and host-pathogen phenotypic interactions.

Keywords: bacteria; breath test; diagnosis; metabolism; phenotype.

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