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Case Reports
. 2015 Jul;90(7):E134-5.
doi: 10.1002/ajh.24009.

Clonal evolution of acute myeloid leukemia relapsed after 19 years of remission

Koichi Takahashi  1   2 , Whijae Roh  3   4 , Jianhua Zhang  5 , Alexei Propotopov  5 , Keyur Patel  6 , Stephen Strickland  7 , Annette Kim  7 , Cindy Vnencak-Jones  7 , Sarah Pelletier  1 , Simrit Parmar  8 , Guillermo Garcia-Manero  1 , Steven Kornblau  1 , Lynda Chin  3   5 , Hagop Kantarjian  1 , P Andrew Futreal  3 , Farhad Ravandi  1
Affiliations
Case Reports

Clonal evolution of acute myeloid leukemia relapsed after 19 years of remission

Koichi Takahashi et al. Am J Hematol. 2015 Jul.
No abstract available

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Conflict of interest statement

Conflict of interest: Authors declare no conflict of interests related to this paper.

Figures

Figure 1
Figure 1
A, B: Two dimensional density plot for cancer cell fraction (CCF) of the detected variants in (A) primary vs. late relapse AML samples and (B) late relapse vs. 2nd remission samples. CCF was estimated by ABSOLUTE algorithm. Each dot represents the variant with corresponding CCF and increasing density indicates the region of high posterior probability of a cluster and thus implies respective clones. C: The inferred model of clonal evolution in a case of AML relapse after 19 years of remission. Y axis shows bone marrow (BM) blast percentage. X axis indicates time. The number in parentheses indicates clone from 2D density plots above. [Color figure can be viewed in the online issue, which is available at wileyonlinelibrary.com.]
See this image and copyright information in PMC

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