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Review
. 2015:2015:138070.
doi: 10.1155/2015/138070. Epub 2015 Feb 24.

Future therapies of wet age-related macular degeneration

Makoto Ishikawa  1 , Daisuke Jin  1 , Yu Sawada  1 , Sanae Abe  1 , Takeshi Yoshitomi  1
Affiliations
Review

Future therapies of wet age-related macular degeneration

Makoto Ishikawa et al. J Ophthalmol. 2015.

Abstract

Age-related macular degeneration (AMD) is the leading cause of blindness in the elderly population, and the prevalence of the disease increases exponentially with every decade after the age of 50 years. While VEGF inhibitors are promising drugs for treating patients with ocular neovascularization, there are limitations to their potential for improving vision in AMD patients. Thus, future therapies are required to have the potential to improve visual outcomes. This paper will summarize the future strategies and therapeutic targets that are aimed at enhancing the efficacy and duration of effect of antiangiogenic strategies.

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References

    1. Friedman D. S., O'Colmain B. J., Muñoz B., et al. Prevalence of age-related macular degeneration in the United States. Archives of Ophthalmology. 2004;122(4):564–572. doi: 10.1001/archopht.122.4.564. - DOI - PubMed
    1. Klein M. L., Francis P. J. Genetics of age-related macular degeneration. Ophthalmology Clinics of North America. 2003;16(4):567–574. doi: 10.1016/S0896-1549(03)00063-4. - DOI - PubMed
    1. Kasuga D. T., Chen Y., Zhang K. Genetics of Age-Related Macular Degeneration. New York, NY, USA: Springer Science+Business Media; 2011. (A. C. Ho and C. D. Regillo, Eds.).
    1. Leung D. W., Cachianes G., Kuang W.-J., Goeddel D. V., Ferrara N. Vascular endothelial growth factor is a secreted angiogenic mitogen. Science. 1989;246(4935):1306–1309. doi: 10.1126/science.2479986. - DOI - PubMed
    1. Keck P. J., Hauser S. D., Krivi G., et al. Vascular permeability factor, an endothelial cell mitogen related to PDGF. Science. 1989;246(4935):1309–1312. doi: 10.1126/science.2479987. - DOI - PubMed