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Comment
. 2015 Mar 23;32(6):663-4.
doi: 10.1016/j.devcel.2015.03.011.

Meiosis: early DNA double-strand breaks pave the way for inter-homolog repair

Valérie Borde  1 , Bernard de Massy  2
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Meiosis: early DNA double-strand breaks pave the way for inter-homolog repair

Valérie Borde et al. Dev Cell. .
Free article

Abstract

During meiotic prophase, the repair of induced DNA double-strand breaks (DSBs) promotes interactions between homologous chromosomes (homologs). A study by Joshi et al. (2015) now highlights how the global DSB activity in a nucleus influences the choice between the homolog and the sister chromatid for DSB repair.

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