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Review
. 2015 Mar 21;21(11):3435-40.
doi: 10.3748/wjg.v21.i11.3435.

Gastrointestinal hemorrhage due to ileal metastasis from primary lung cancer

Wei Liu  1 , Wei Zhou  1 , Wei-Lin Qi  1 , Ya-Dan Ma  1 , Yun-Yun Xu  1
Affiliations
Review

Gastrointestinal hemorrhage due to ileal metastasis from primary lung cancer

Wei Liu et al. World J Gastroenterol. .

Abstract

We report a patient with small intestinal metastasis from lung squamous cell carcinoma. A 66-year-old man who underwent radical lung cancer surgery was admitted to our hospital. Before starting his fifth cycle of chemotherapy, he was found to have a positive fecal occult blood test. Abdominal computed tomography scan revealed an ileal tumor with mesenteric lymph node enlargement. He underwent laparoscopic resection of the involved small intestine and mesentery. Histopathological analysis confirmed metastasis from lung cancer. We conducted a review of the literature and 64 documented cases of small intestinal metastasis from lung cancer were found. The pathologic diagnosis, clinical presentation, site of metastasis, and survival time in these cases were reviewed.

Keywords: Gastrointestinal hemorrhage; Gastrointestinal neoplasms; Lung cancer; Metastasis; Small intestine.

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Figures

Figure 1
Figure 1
Abdominal computed tomography scan revealed metastatic tumor mass of ileum (solid arrow) and the enlarged lymph node (dotted arrow).
Figure 2
Figure 2
Intraoperative imaging of the resected tumor of the ileum. The tumor was 4.5 cm × 3.0 cm in size, with a clear margin and ulceration on the intraluminal surface.
Figure 3
Figure 3
Microscopic findings of metastatic lung squamous cell carcinoma in the ileum.
Figure 4
Figure 4
By immunohistochemistry, the tumor cells were found to be positive for CKH (A) and P63 (B), but negative for CK20 (C) and CK7 (D).
See this image and copyright information in PMC

References

    1. Siegel R, Naishadham D, Jemal A. Cancer statistics, 2013. CA Cancer J Clin. 2013;63:11–30. - PubMed
    1. Hoffman PC, Mauer AM, Vokes EE. Lung cancer. Lancet. 2000;355:479–485. - PubMed
    1. Song Y, Li M, Shan J, Ye X, Tang S, Fang X, Ding K, Yuan Y. Acute small bowel obstruction: a rare initial presentation for the metastasis of the large-cell carcinoma of the lung. World J Surg Oncol. 2012;10:26. - PMC - PubMed
    1. Salemis NS, Nikou E, Liatsos C, Gakis C, Karagkiouzis G, Gourgiotis S. Small bowel perforation secondary to metastatic non-small cell lung cancer. A rare entity with a dismal prognosis. J Gastrointest Cancer. 2012;43:391–395. - PubMed
    1. Mulder MC, Kist JW, Consten EC, Verheijen PM. Gastrointestinal metastasis as the first presentation of lung carcinoma. Int J Colorectal Dis. 2012;27:839–840. - PubMed

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