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. 2015 Apr 17;17(8):1906-9.
doi: 10.1021/acs.orglett.5b00601. Epub 2015 Mar 25.

Copper-mediated radical 1,2-bis(trifluoromethylation) of alkenes with sodium trifluoromethanesulfinate

Bin Yang  1 , Xiu-Hua Xu  1 , Feng-Ling Qing  1   2
Affiliations

Copper-mediated radical 1,2-bis(trifluoromethylation) of alkenes with sodium trifluoromethanesulfinate

Bin Yang et al. Org Lett. .

Abstract

An efficient chemoselective 1,2-bis(trifluoromethylation) of alkenes with CF3SO2Na promoted by t-BuOOH/CuCl was developed. This protocol provided the first convenient preparation of 1,2-bis(trifluoromethylated) compounds by the vicinal difunctionalization of alkenes. The chemoselectivity of this reaction was accomplished by increasing the concentration of the CF3 radical.

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