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. 1985;10(5-6):276-7.
doi: 10.1007/BF00254474.

Spermidine level as a parameter in the treatment of patients with malignant melanoma

J M Smit, H Jurjens, J Bouman, J Bijzet, D T Sleijfer, M G Woldring, N H Mulder

Spermidine level as a parameter in the treatment of patients with malignant melanoma

J M Smit et al. Eur J Nucl Med. 1985.

Abstract

Before, during, and after 19 courses of chemotherapy given to patients with disseminated malignant melanoma plasma spermidine levels were determined with a radioimmunoassay. Baseline values were normal in 17 courses, a doubling of plasma levels following chemotherapy occurred in 13 courses. There was no relation between the occurrence of a tumor response and an increase in spermidine levels nor between hematological toxicity or digestive tract toxicity and spermidine levels.

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