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Review
. 2015 Jan-Mar;13(1):117-21.
doi: 10.1590/S1679-45082015RW2874. Epub 2015 Mar 24.

Association between increased serum thyrotropin concentration and the oldest old: what do we know?

[Article in English, Portuguese]
Glaucia Cruzes Duarte  1 , Maysa Seabra Cendoroglo  1 , Lara Miguel Quirino Araújo  1 , Clineu de Mello Almada Filho  1
Affiliations
Review

Association between increased serum thyrotropin concentration and the oldest old: what do we know?

[Article in English, Portuguese]
Glaucia Cruzes Duarte et al. Einstein (Sao Paulo). 2015 Jan-Mar.

Abstract
in English, Portuguese

To assess studies that evaluate the relation between serum thyrotropin concentration, very old subjects, and their events. We searched the PubMed, SciELO, and LILACS databases for articles published between 2004 and 2012. Our search was restricted to studies involving humans aged 65 years or older, and written in English, Spanish, or Portuguese. Studies that evaluated the association between elevated serum thyrotropin concentration among elderly subjects with subclinical hypothyroidism were chosen since at least in part they included a subpopulation of individuals aged 80 years and above. Thirteen studies were selected. No significant increase in risk of cardiovascular events, coronary heart disease, or total mortality was observed. Elevated thyrotropin concentration was associated with longevity. More randomized controlled trials are required to better define the potential benefits of elevated thyrotropin concentration in this oldest old population, hormone replacement, and longevity.

Avaliar os artigos que consideram a relação entre a concentração da tirotropina sérica, indivíduos muito idosos e seus eventos. Foram selecionados artigos do PubMed, SciELO e LILACS publicados entre 2004 e 2012, que consideraram uma população ≥65 anos, escritos em inglês, espanhol ou português. Os estudos que avaliaram a associação entre níveis séricos elevados de tirotropina sérica e idosos com hipotireoidismo subclínico foram escolhidos, desde que incluíssem uma subpopulação com 80 anos ou mais. Treze estudos foram selecionados. Não houve associação significante entre maior risco de eventos cardiovasculares, doença coronariana ou mortalidade. A concentração elevada de tirotropina sérica foi associada à longevidade. Mais estudos randomizados controlados são necessários para o melhor entendimento do potencial benefício da elevação de concentração da tirotropina sérica nos longevos, reposição hormonal e longevidade.

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Figures

Figure 1
Figure 1. Criteria applied for selection of the studies
Figura 1
Figura 1. Critérios aplicados para seleção de estudos
See this image and copyright information in PMC

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