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. 2015 Jul;17(7):532-7.
doi: 10.1111/jch.12533. Epub 2015 Mar 23.

Increased Neutrophil to Lymphocyte Ratio in Patients With Resistant Hypertension

Erdal Belen  1 , Aylin Sungur  2 , Mustafa Azmi Sungur  2 , Güney Erdoğan  3
Affiliations

Increased Neutrophil to Lymphocyte Ratio in Patients With Resistant Hypertension

Erdal Belen et al. J Clin Hypertens (Greenwich). 2015 Jul.

Abstract

Resistant hypertension (RHT) is an important disease that causes an increase in cardiovascular risk, yet its etiology remains unclear. The authors aimed to investigate neutrophil/lymphocyte ratio (NLR) as an inflammation marker in patients with RHT. A total of 150 patients were included in the study and grouped according to their office and ambulatory blood pressure measurements. They were classified as having normotension (NT), controlled hypertension (CHT), or RHT. The RHT group had a significantly higher NLR than the CHT group (P=.03), and NLRs of both hypertension groups were significantly higher than those in the NT group (P<.001, for both). NLR and neutrophil count were found to be independent correlates for RHT in multivariate analysis (P<.001). NLR and neutrophil count are increased in RHT patients than both CHT and NT patients. This finding, which is defined for the first time in patients with RHT, may imply the importance of inflammation in blood pressure control.

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Figures

Figure 1
Figure 1
Neutrophil lymphocyte ratios (NLR) of normotension (NT), controlled hypertension (CHT) and resistant hypertension (RHT) groups.
See this image and copyright information in PMC

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