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Review
. 2015 May;26(5):249-56.
doi: 10.1089/hum.2015.028. Epub 2015 Apr 20.

Improved in vitro human tumor models for cancer gene therapy

Philip G Jakeman  1 , Thomas E Hills  1 , Alison B Tedcastle  1 , Ying Di  1 , Kerry D Fisher  1 , Leonard W Seymour  1
Affiliations
Review

Improved in vitro human tumor models for cancer gene therapy

Philip G Jakeman et al. Hum Gene Ther. 2015 May.

Abstract

Developing effective anticancer treatments is a particular challenge, as agents must contend with not only the target cellular biology, but also with the complex tumor microenvironment. Here we discuss various in vitro strategies that have sought to address this issue, with a particular focus on new methodologies that utilize clinical samples in basic research and their application in gene therapy and virotherapy.

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