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. 2015 Jul;67(7):1978-80.
doi: 10.1002/art.39123.

DNA Methylome Signature in Synoviocytes From Patients With Early Rheumatoid Arthritis Compared to Synoviocytes From Patients With Longstanding Rheumatoid Arthritis

Rizi Ai  1 , John W Whitaker  1 , David L Boyle  1 , Paul Peter Tak  2 , Danielle M Gerlag  2 , Wei Wang  1 , Gary S Firestein  1
Affiliations

DNA Methylome Signature in Synoviocytes From Patients With Early Rheumatoid Arthritis Compared to Synoviocytes From Patients With Longstanding Rheumatoid Arthritis

Rizi Ai et al. Arthritis Rheumatol. 2015 Jul.
No abstract available

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Figures

Figure 1
Figure 1
Analysis of DNA methylation patterns in early and longstanding rheumatoid arthritis. (A) Hierarchical clustering of longstanding RA, (LRA), early RA (ERA), juvenile idiopathic arthritis (JIA) and osteoarthritis (OA) based on differentially methylated loci. (B) Analysis of the first three principal components of longstanding RA, (LRA), early RA (ERA), juvenile idiopathic arthritis (JIA) and osteoarthritis (OA) based on differentially methylated loci. Note that the inflammatory arthritis samples mainly cluster together, and that ERA segregates from JIA.
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References

    1. Nakano K, Whitaker JW, Boyle DL, Wang W, Firestein GS. DNA methylome signature in rheumatoid arthritis. Ann Rheum Dis. 2013;72:110–7. - PMC - PubMed
    1. Whitaker JW, Shoemaker R, Boyle DL, Hillman J, Anderson D, Wang W, et al. An imprinted rheumatoid arthritis methylome signature reflects pathogenic phenotype. Genome Med. 2013;5:40. - PMC - PubMed
    1. Bartok B, Firestein GS. Fibroblast-like synoviocytes: key effector cells in rheumatoid arthritis. Immunol Rev. 2010;233:233–55. - PMC - PubMed
    1. van de Sande MG, de Hair MJ, Schuller Y, van de Sande GP, Wijbrandts CA, Dinant HJ, et al. The features of the synovium in early rheumatoid arthritis according to the 2010 ACR/EULAR classification criteria. PLoS One. 2012;7:e36668. - PMC - PubMed
    1. Aletaha D, Neogi T, Silman AJ, Funovits J, Felson DT, Bingham CO, et al. 2010 Rheumatoid arthritis classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative. Arthritis Rheum. 2010;62:2569–81. - PubMed

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