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Randomized Controlled Trial
. 2016 Jan;25(1):43-50.
doi: 10.1002/pon.3799. Epub 2015 Mar 23.

Reliable change in neuropsychological assessment of breast cancer survivors

Charissa Andreotti  1 , James C Root  1 , Sanne B Schagen  2 , Brenna C McDonald  3 , Andrew J Saykin  3 , Thomas M Atkinson  1 , Yuelin Li  1 , Tim A Ahles  1
Affiliations
Randomized Controlled Trial

Reliable change in neuropsychological assessment of breast cancer survivors

Charissa Andreotti et al. Psychooncology. 2016 Jan.

Abstract

Background: The purpose of this study was to enhance the current understanding and interpretation of longitudinal change on tests of neurocognitive function in individuals with cancer. Scores on standard neuropsychological instruments may be impacted by practice effects and other random forms of error.

Methods: The current study assessed the test-retest reliability of several tests and overarching cognitive domains comprising a neurocognitive battery typical of those used for research and clinical evaluation using relevant time frames. Practice effect-adjusted reliable change confidence intervals for test-retest difference scores based on a sample of patient-matched healthy controls are provided.

Results: By applying reliable change confidence intervals to scores from two samples of breast cancer patients at post-treatment follow-up assessment, meaningful levels of detectable change in cognitive functioning in breast cancer survivors were ascertained and indicate that standardized neuropsychological instruments may be subject to limitations in detection of subtle cognitive dysfunction over clinically relevant intervals, especially in patient samples with average to above average range baseline functioning.

Conclusions: These results are discussed in relation to reported prevalence of cognitive change in breast cancer patients along with recommendations for study designs that enhance detection of treatment effects.

Keywords: breast cancer; cognition; neuropsychological assessment; survivorship.

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Conflict of interest statement

Conflict of interest

The authors have declared no conflicts of interest.

References

    1. Ahles TA, Root JC, Ryan EL. Cancer- and cancer treatment-associated cognitive change: an update on the state of the science. J Clin Oncol. 2012;30(30):3675–3686. - PMC - PubMed
    1. Hutchinson AD, Mathias JL. Neuropsychological deficits in frontotemporal dementia and Alzheimer’s disease: a meta-analytic review. J Neurol Neurosurg Psychiatry. 2007;78(9):917–928. - PMC - PubMed
    1. Mathias JL, Wheaton P. Changes in attention and information-processing speed following severe traumatic brain injury: a meta-analytic review. Neuropsychology. 2007;21(2):212–223. - PubMed
    1. Shilling V, Jenkins V, Trapala IS. The (mis) classification of chemo-fog–methodological inconsistencies in the investigation of cognitive impairment after chemotherapy. Breast Cancer Res Treat. 2006;95(2):125–129. - PubMed
    1. Ahles TA, Saykin AJ, McDonald BC, et al. Longitudinal assessment of cognitive changes associated with adjuvant treatment for breast cancer: impact of age and cognitive reserve. J Clin Oncol. 2010;28(29):4434–4440. - PMC - PubMed

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