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. 2016 Apr:38 Suppl 1:E559-65.
doi: 10.1002/hed.24039. Epub 2015 Jul 6.

Toxicity and efficacy of accelerated radiotherapy with concurrent weekly cisplatin for locally advanced head and neck carcinoma

Chantal M L Driessen  1 , Geert O Janssens  2 , Winette T A van der Graaf  1 , Robert P Takes  3 , Thijs A W Merkx  4 , Willem J G Melchers  5 , Hans A M Kaanders  2 , Carla M L van Herpen  1
Affiliations

Toxicity and efficacy of accelerated radiotherapy with concurrent weekly cisplatin for locally advanced head and neck carcinoma

Chantal M L Driessen et al. Head Neck. 2016 Apr.

Abstract

Background: The purpose of this report was to present the results of accelerated radiotherapy (RT) with concomitant weekly cisplatin in head and neck cancer.

Methods: One hundred six patients received concomitant cisplatin 40 mg/m(2) weekly with accelerated RT up to a dose of 68 Gy over 5.5 weeks.

Results: Ninety-nine percent of the patients received planned RT and 90% received ≥5 cycles of cisplatin. Moist desquamation of skin developed in 45% and confluent mucositis in 82%. Feeding tubes were required in 79% of the patients, and after 12 months in 4%. One patient developed nephrotoxicity. Three-year locoregional control, disease-free survival (DFS), and overall survival (OS) were 72%, 54%, and 61%, respectively. Human papillomavirus (HPV) status was positive on polymerase chain reaction (PCR) and p16 in 11 of 50 patients with oropharyngeal carcinoma. Three-year OS was 81% and 66% in HPV-positive versus HPV-negative patients with oropharyngeal carcinoma.

Conclusion: Concomitant weekly cisplatin 40 mg/m(2) with accelerated RT was well tolerated and treatment compliance was high. © 2015 Wiley Periodicals, Inc. Head Neck 38: E559-E565, 2016.

Keywords: accelerated; chemotherapy; head neck cancer; radiotherapy; weekly cisplatin.

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