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Practice Guideline
. 2015 Aug;62(8):1305-16.
doi: 10.1002/pbc.25501. Epub 2015 Mar 21.

SIOP-PODC adapted risk stratification and treatment guidelines: Recommendations for neuroblastoma in low- and middle-income settings

Nehal S Parikh  1 , Scott C Howard  2 , Guillermo Chantada  3 , Trijn Israels  4 , Mohammed Khattab  5 , Patricia Alcasabas  6 , Catherine G Lam  7 , Lawrence Faulkner  8 , Julie R Park  9 , Wendy B London  10 , Katherine K Matthay  11 ; International Society of Pediatric Oncology
Affiliations
Practice Guideline

SIOP-PODC adapted risk stratification and treatment guidelines: Recommendations for neuroblastoma in low- and middle-income settings

Nehal S Parikh et al. Pediatr Blood Cancer. 2015 Aug.

Abstract

Neuroblastoma is the most common extracranial solid tumor in childhood in high-income countries (HIC), where consistent treatment approaches based on clinical and tumor biological risk stratification have steadily improved outcomes. However, in low- and middle- income countries (LMIC), suboptimal diagnosis, risk stratification, and treatment may occur due to limited resources and unavailable infrastructure. The clinical practice guidelines outlined in this manuscript are based on current published evidence and expert opinions. Standard risk stratification and treatment explicitly adapted to graduated resource settings can improve outcomes for children with neuroblastoma by reducing preventable toxic death and relapse.

Keywords: MYCN; Neuroblastoma; diagnosis; low income countries; resource limited countries; treatment.

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