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Review
. 2015 Jan-Mar;36(1):24-31.
doi: 10.4103/0971-5851.151771.

Harmful effects of nicotine

Aseem Mishra  1 , Pankaj Chaturvedi  1 , Sourav Datta  1 , Snita Sinukumar  1 , Poonam Joshi  1 , Apurva Garg  1
Affiliations
Review

Harmful effects of nicotine

Aseem Mishra et al. Indian J Med Paediatr Oncol. 2015 Jan-Mar.

Abstract

With the advent of nicotine replacement therapy, the consumption of the nicotine is on the rise. Nicotine is considered to be a safer alternative of tobacco. The IARC monograph has not included nicotine as a carcinogen. However there are various studies which show otherwise. We undertook this review to specifically evaluate the effects of nicotine on the various organ systems. A computer aided search of the Medline and PubMed database was done using a combination of the keywords. All the animal and human studies investigating only the role of nicotine were included. Nicotine poses several health hazards. There is an increased risk of cardiovascular, respiratory, gastrointestinal disorders. There is decreased immune response and it also poses ill impacts on the reproductive health. It affects the cell proliferation, oxidative stress, apoptosis, DNA mutation by various mechanisms which leads to cancer. It also affects the tumor proliferation and metastasis and causes resistance to chemo and radio therapeutic agents. The use of nicotine needs regulation. The sale of nicotine should be under supervision of trained medical personnel.

Keywords: Addiction; cancer; cardiovascular; gastrointestinal; nicotine; respiratory.

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Conflict of interest statement

Conflict of Interest: None declared.

References

    1. WHO Data. Tobacco Fact Sheet; No. 339. [Last accessed on 2015 Jan 29]. Available from: http://www.who.int/mediacentre/factsheets/fs339/en .
    1. WHO Framework Convention on Tobacco Control. [Last accessed on 2014 Sep 27]. Available from: http://www.who.int/fctc/about/en .
    1. Fagerström K. The nicotine market: An attempt to estimate the nicotine intake from various sources and the total nicotine consumption in some countries. Nicotine Tob Res. 2005;7:343–50. - PubMed
    1. US Environmental Protection Agency. Nicotine: Product cancellation order. Fed Regist. 2009. [Last accessed 2014 Nov 01]. Available from: http://www.epa.gov/fedrgstr/EPA-PEST/2009/June/Day-03/p12561.htm .
    1. APIB. Banned Pesticides. [Last updated on 2002 Mar 25; Last accessed on 2014 Sep 27]. Available from: http://megapib.nic.in/Int_pest_bannedPest.htm .