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. 2015 Jan-Jun;6(1):49-55.
doi: 10.4103/0976-9668.149077.

The clinical efficacy of using autologous platelet rich plasma in hip arthroplasty: A retrospective comparative study

Atif Safdar  1 , Hamid Shaaban  2 , Restituto Tibayan  2 , Richard Miller  1 , Richard Boairdo  3 , Gunwant Guron  2
Affiliations

The clinical efficacy of using autologous platelet rich plasma in hip arthroplasty: A retrospective comparative study

Atif Safdar et al. J Nat Sci Biol Med. 2015 Jan-Jun.

Abstract

Background: Platelet rich plasma (PRP) is a blood derivative concentrate of platelets, fibrin and growth factors obtained through withdrawal and centrifugation of autologous blood and use for its inherent hemostatic and adhesive properties to promote wound healing. Hip arthroplasty is often associated with significant perioperative complications including blood loss necessitating blood transfusions, which can lead to multiple adverse reactions, infection transmission, and longer hospital stay.

Materials and methods: We conducted this retrospective comparative study to determine whether the use of PRP can reduce the bleeding complications in hip replacement surgeries and therefore decrease analgesic requirements and shorten the hospital stay.

Results: Sixty patients had consecutive hip replacement surgeries. The study group (n=23) received PRP applications while the control group (n=37) were operated without PRP applications. Postoperative drop of hemoglobin, number of red blood cell (RBC) transfusions, analgesic requirements, and duration of hospital stay were recorded. There was no significant difference in the drop of hemoglobin preoperatively and postoperatively comparing study and control groups (P=0.75). There was no difference in transfusion requirements between the two groups (P=0.16) but there was trend toward less transfusion in the PRP-treated group. There were also no statistical differences in analgesic use (P=0.83) and lengths of hospitalization (P=0.68) between the two groups.

Conclusion: We concluded that there is no clinical efficacy in using PRP in hip replacement surgeries. We recommend a larger prospective study be conducted to determine its clinical utility as an optimization strategy to improve outcome after hip arthroplasty.

Keywords: Autologous; hip arthroplasty; platelet rich plasma.

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Conflict of interest statement

Conflict of Interest: None declared.

Figures

Figure 1
Figure 1
When the PRP and non-PRP-treated groups were compared, there was no significant difference in the drop of hemoglobin (P=0.75)
Figure 2
Figure 2
The mean number of transfused red blood cells (RBCs) in PRP-treated group was 0.39 units while 1.05 were transfused in the untreated control. There appeared to be a trend toward less transfusion, however, this did not reach statistical significance (P=0.16). There was no significant difference (P=0.78) [RR=0.87, 95% CI 0.41–2.85] between subjects in the study and control groups.
Figure 3
Figure 3
There was no significant difference in the length of hospital stay between the groups (P=0.68). The length of stay for PRP-treated and control groups were 3.56 and 3.51 days, respectively
See this image and copyright information in PMC

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