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. 1985 Feb;328(4):378-81.
doi: 10.1007/BF00692904.

The positive inotropic dihydropyridine Bay K 8644 does not affect calcium sensitivity or calcium release of skinned cardiac fibres

G Thomas, R Gross, G Pfitzer, J C Rüegg

The positive inotropic dihydropyridine Bay K 8644 does not affect calcium sensitivity or calcium release of skinned cardiac fibres

G Thomas et al. Naunyn Schmiedebergs Arch Pharmacol. 1985 Feb.

Abstract

BAY K 8644 is a positive inotropic dihydropyridine which concentration-dependently increased contractile force in guinea-pig atria at 10 to 1000 nmol/l. In chemically skinned cardiac fibres from guinea-pig hearts the substance did not change the tension induced by calcium. Also BAY K 8644 did not release calcium from intracellular myocardial stores like caffeine since it failed to evoke a contractile response in saponin-treated, calcium-loaded cardiac muscle. Thus, the drug exerts its effects neither by sensitizing the contractile apparatus to calcium nor by a caffeine-like action.

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References

    1. Naunyn Schmiedebergs Arch Pharmacol. 1977 Jul;298(3):267-72 - PubMed
    1. Pflugers Arch. 1982 Oct;395(1):49-54 - PubMed
    1. FEBS Lett. 1984 Feb 13;167(1):88-92 - PubMed
    1. Arzneimittelforschung. 1972 Feb;22(2):334-44 - PubMed
    1. Naunyn Schmiedebergs Arch Pharmacol. 1983 Jun;323(2):85-9 - PubMed

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