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. 2015 Apr;21(4):702-4.
doi: 10.3201/eid2104.142012.

Safety of recombinant VSV-Ebola virus vaccine vector in pigs

Emmie de Wit, Andrea Marzi, Trenton Bushmaker, Doug Brining, Dana Scott, Juergen A Richt, Thomas W Geisbert, Heinz Feldmann

Safety of recombinant VSV-Ebola virus vaccine vector in pigs

Emmie de Wit et al. Emerg Infect Dis. 2015 Apr.

Abstract

The ongoing Ebola outbreak in West Africa has resulted in fast-track development of vaccine candidates. We tested a vesicular stomatitis virus vector expressing Ebola virus glycoprotein for safety in pigs. Inoculation did not cause disease and vaccine virus shedding was minimal, which indicated that the vaccine virus does not pose a risk of dissemination in pigs.

Keywords: Ebola virus; VSV; VSV vaccine; pigs; recombinant VSV–Ebola virus vaccine vector; safety; vaccines; vesicular stomatitis viruses; viruses; zoonoses.

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