doi: 10.1016/0304-3940(85)90302-7.
Stereoselectivity of L-baclofen in hippocampal slices of the rat
- PMID: 2581185
- DOI: 10.1016/0304-3940(85)90302-7
Item in Clipboard
Stereoselectivity of L-baclofen in hippocampal slices of the rat
Neurosci Lett.
.
Abstract
Extra- and intracellular recording from hippocampal slices of the rat revealed the following effects when baclofen (BF) (0.1-10 microM) was added to the perfusion fluid: a block of synaptic potentials evoked by stimulation of stratum radiatum; a direct hyperpolarization and a conductance increase (for potassium ions) of CA1 pyramidal cells. All this activity was found in the L- none in the D-enantiomer. D-BF did not antagonize the action of L-BF.
Similar articles
-
Adenosine enhances afterhyperpolarization and accommodation in hippocampal pyramidal cells.Pflugers Arch. 1984 Nov;402(3):244-7. doi: 10.1007/BF00585506. Pflugers Arch. 1984. PMID: 6097865
-
Comparison of the action of baclofen with gamma-aminobutyric acid on rat hippocampal pyramidal cells in vitro.J Physiol. 1985 Mar;360:161-85. doi: 10.1113/jphysiol.1985.sp015610. J Physiol. 1985. PMID: 3989713 Free PMC article.
-
Differences in baclofen-sensitivity between CA3 neurons and granule cells of the guinea pig hippocampus in vitro.Neurosci Lett. 1984 Jun 29;47(3):307-11. doi: 10.1016/0304-3940(84)90531-7. Neurosci Lett. 1984. PMID: 6089049
-
GABA and baclofen reduce changes in extracellular free calcium in area CA1 of rat hippocampal slices.Neurosci Lett. 1984 Jun 29;47(3):295-300. doi: 10.1016/0304-3940(84)90529-9. Neurosci Lett. 1984. PMID: 6089047
-
Baclofen reduces post-synaptic potentials of rat cortical neurones by an action other than its hyperpolarizing action.J Physiol. 1987 Mar;384:539-69. doi: 10.1113/jphysiol.1987.sp016469. J Physiol. 1987. PMID: 3309263 Free PMC article. Review.
Cited by
-
Bidirectional enantioselective effects of the GABAB receptor agonist baclofen in two mouse models of excessive ethanol consumption.Alcohol. 2015 Feb;49(1):37-46. doi: 10.1016/j.alcohol.2014.11.005. Epub 2014 Dec 17. Alcohol. 2015. PMID: 25557834 Free PMC article.
-
Stereospecific actions of baclofen on sociosexual behavior, locomotor activity and motor execution.Psychopharmacology (Berl). 1989;97(3):358-64. doi: 10.1007/BF00439451. Psychopharmacology (Berl). 1989. PMID: 2497485
-
Fragile X syndrome: an update on developing treatment modalities.ACS Chem Neurosci. 2011 Aug 17;2(8):402-10. doi: 10.1021/cn200019z. Epub 2011 Mar 22. ACS Chem Neurosci. 2011. PMID: 22860169 Free PMC article. Review.
-
Blockade of gamma-aminobutyric acid-receptors of the B-subtype inhibits the dopamine-induced enhancement of the release of cholecystokinin-like immunoreactivity from slices of rat dorsal caudatoputamen.Naunyn Schmiedebergs Arch Pharmacol. 1987 May;335(5):541-6. doi: 10.1007/BF00169121. Naunyn Schmiedebergs Arch Pharmacol. 1987. PMID: 3039381
-
Intrathecal baclofen for long-term treatment of spasticity: a multi-centre study.J Neurol Neurosurg Psychiatry. 1989 Aug;52(8):933-9. doi: 10.1136/jnnp.52.8.933. J Neurol Neurosurg Psychiatry. 1989. PMID: 2487035 Free PMC article. Clinical Trial.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Miscellaneous
