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. 1985 Mar 22;55(1):1-4.
doi: 10.1016/0304-3940(85)90302-7.

Stereoselectivity of L-baclofen in hippocampal slices of the rat

H L Haas, R W Greene, H R Olpe

Stereoselectivity of L-baclofen in hippocampal slices of the rat

H L Haas et al. Neurosci Lett. .

Abstract

Extra- and intracellular recording from hippocampal slices of the rat revealed the following effects when baclofen (BF) (0.1-10 microM) was added to the perfusion fluid: a block of synaptic potentials evoked by stimulation of stratum radiatum; a direct hyperpolarization and a conductance increase (for potassium ions) of CA1 pyramidal cells. All this activity was found in the L- none in the D-enantiomer. D-BF did not antagonize the action of L-BF.

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