Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2015 Apr 28;44(16):7135-8.
doi: 10.1039/c5dt00175g.

Enhanced cancer cell killing of a Pt(IV) prodrug promoted by outer-sphere coordination with polyethyleneimines

A Garaikoetxea Arguinzoniz  1 , N Gómez Blanco, P Ansorena Legarra, J C Mareque-Rivas
Affiliations

Enhanced cancer cell killing of a Pt(IV) prodrug promoted by outer-sphere coordination with polyethyleneimines

A Garaikoetxea Arguinzoniz et al. Dalton Trans. .

Abstract

The cisplatin prodrug c,c,t-[Pt(NH3)2Cl2(O2CCH2CH2CO2)2](2-) (1) forms outer-sphere coordination interactions with non-toxic low MW PEI, which results in enhanced cancer cell killing, also achieved using PEI-coated AuNPs.

PubMed Disclaimer

Publication types

LinkOut - more resources