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. 2015 Mar-Apr;60(2):212.
doi: 10.4103/0019-5154.152572.

Fluconazole-induced acute generalized exanthematous pustulosis

Vito Di Lernia  1 , Cinzia Ricci  1
Affiliations

Fluconazole-induced acute generalized exanthematous pustulosis

Vito Di Lernia et al. Indian J Dermatol. 2015 Mar-Apr.

Abstract

Acute generalized exanthematous pustulosis (AGEP) is a severe cutaneous adverse reaction and is usually caused by drugs. It is characterized by fever and acute, extensive occurrence of disseminated sterile pustules, accompanied by fever, malaise and peripheral blood leucocytosis. There have been several reports to date of AGEP following exposure to antifungals. In particular, terbinafine is included in the list of the agents conferring the highest risk of AGEP. The authors report the case of a 70-year-old male patient who developed AGEP shortly after commencing treatment with fluconazole, which has been reported in association with AGEP in a single case report. To our knowledge, this is the first reported case of AGEP associated with positive fluconazole patch test.

Keywords: Antifungals; drug; patch test; reaction; skin.

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Conflict of interest statement

Conflict of Interest: Nil.

Figures

Figure 1
Figure 1
Disseminated pinhead pustules on erythematous background on the trunk
Figure 2
Figure 2
Confluence of pustules on a wrist
Figure 3
Figure 3
Histological examination: Subcorneal and intraepidermal pustule; papillary edema and a diffuse, polymorphous perivascular infiltrate can also be noted in the papillary dermis. H and E (original magnification ×200)
See this image and copyright information in PMC

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