Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2015 Mar-Apr;60(2):212.
doi: 10.4103/0019-5154.152572.

Fluconazole-induced acute generalized exanthematous pustulosis

Vito Di Lernia  1 , Cinzia Ricci  1
Affiliations

Fluconazole-induced acute generalized exanthematous pustulosis

Vito Di Lernia et al. Indian J Dermatol. 2015 Mar-Apr.

Abstract

Acute generalized exanthematous pustulosis (AGEP) is a severe cutaneous adverse reaction and is usually caused by drugs. It is characterized by fever and acute, extensive occurrence of disseminated sterile pustules, accompanied by fever, malaise and peripheral blood leucocytosis. There have been several reports to date of AGEP following exposure to antifungals. In particular, terbinafine is included in the list of the agents conferring the highest risk of AGEP. The authors report the case of a 70-year-old male patient who developed AGEP shortly after commencing treatment with fluconazole, which has been reported in association with AGEP in a single case report. To our knowledge, this is the first reported case of AGEP associated with positive fluconazole patch test.

Keywords: Antifungals; drug; patch test; reaction; skin.

PubMed Disclaimer

Conflict of interest statement

Conflict of Interest: Nil.

Figures

Figure 1
Figure 1
Disseminated pinhead pustules on erythematous background on the trunk
Figure 2
Figure 2
Confluence of pustules on a wrist
Figure 3
Figure 3
Histological examination: Subcorneal and intraepidermal pustule; papillary edema and a diffuse, polymorphous perivascular infiltrate can also be noted in the papillary dermis. H and E (original magnification ×200)
See this image and copyright information in PMC

References

    1. Beylot C, Bioulac P, Doutre MS. Acute generalized exanthematic pustuloses (four cases) Ann Dermatol Venéol. 1980;107:37–48. - PubMed
    1. Roujeau JC, Bioulac-Sage P, Bourseau C, Guillaume JC, Bernard P, Lok C, et al. Acute generalized exanthematous pustulosis. Analysis of 63 cases. Arch Dermatol. 1991;127:1333–8. - PubMed
    1. Di Lernia V, Grenzi L, Guareschi E, Ricci C. Rapid clearing of acute generalized exanthematous pustulosis after administration of ciclosporin. Clin Exp Dermatol. 2009;34:e757–9. - PubMed
    1. Gencoglan G, Tosun M, Aktepe F. The molecular mechanism of etanercept, an anti-tumour necrosis factor-alpha receptor-fusion protein, in the treatment of acute generalized exanthematous pustulosis. J Dermatolog Treat. 2009;20:241–5. - PubMed
    1. Barbaud A, Collet E, Milpied B, Assier H, Staumont D, Avenel-Audran M, et al. A multicenter study to determine the value and safety of drug patch tests for the three main classes of severe cutaneous adverse drug reactions. Br J Dermatol. 2013;168:555–62. - PubMed