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Review
. 2015 Mar-Apr;32(2):142-51.
doi: 10.4103/0970-2113.152626.

Anemia in Chronic obstructive pulmonary disease: Prevalence, pathogenesis, and potential impact

Malay Sarkar  1 , Puja Negi Rajta  2 , Jasmin Khatana  3
Affiliations
Review

Anemia in Chronic obstructive pulmonary disease: Prevalence, pathogenesis, and potential impact

Malay Sarkar et al. Lung India. 2015 Mar-Apr.

Abstract

Chronic obstructive pulmonary disease (COPD) is a common preventable and treatable lifestyle-related disease with high global prevalence. COPD is associated with significant morbidity and mortality worldwide. Comorbidities are important events in the natural history of the disease and have a negative effect on the morbidity and mortality of COPD patients. Cardiac diseases, lung cancer, osteoporosis, and depression are common comorbidities reported for COPD. Recently, anemia has been recognized as a frequent comorbidity in COPD patients. The prevalence of anemia in patients with COPD varies from 7.5% to 33%. Anemia of chronic disease (ACD) is probably the most common type of anemia associated with COPD. ACD is driven by COPD-mediated systemic inflammation. Anemia in COPD is associated with greater healthcare resource utilization, impaired quality of life, decreased survival, and a greater likelihood of hospitalization. We need large prospective studies to discern the association between anemia and COPD.

Keywords: Anemia of chronic disease; anemia; chronic obstructive pulmonary disease.

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Conflict of interest statement

Conflict of Interest: None declared.

Figures

Figure 1
Figure 1
The IL-6/Hepcidin/Ferroportin axis
Figure 2
Figure 2
Various mechanisms of anemia in COPD
See this image and copyright information in PMC

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