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. 2014 Nov;10(6):305-10.

Rheumatoid factor, anti-nuclear antibody in ischemic heart disease: Acute versus chronic patients

Akram Sedaghat  1 , Masoumeh Sadeghi  2 , Ramin Heidari  3 , Efat Sistani  4 , Zahra Bayanfar  5
Affiliations

Rheumatoid factor, anti-nuclear antibody in ischemic heart disease: Acute versus chronic patients

Akram Sedaghat et al. ARYA Atheroscler. 2014 Nov.

Abstract

Background: Immunopathological and inflammatory processes play important roles in the initiation and development of ischemic heart disease. Hence, this study aimed to evaluate the relationship between serum levels rheumatoid factor (RF) and anti-nuclear antibodies (ANA) and severity of coronary stenotic lesions.

Methods: Totally 140 patients with acute coronary syndrome (ACS) (n = 70) and chronic stable angina (CSA) (n = 70) that undergoing coronary angiography were enrolled in this study. ANA by the enzyme-linked immunosorbent assay (ELISA) and serum level of RF was measured by latex method. The severity of coronary stenotic lesions calculated by Gensini score. To analyze the correlations of ANA and RF to Gensini score Pearson correlation test was used. To adjust the effect of age and other confounder factors such hypertension, diabetes, hyperlipidemia and smoking multiple linear regression was used.

Results: The mean serum levels of RF and ANA in CSA group were significantly higher than ACS group after adjusting for the confounder factors (P < 0.050 for ANA). Serum levels of ANA significantly correlated with severity of coronary stenotic lesions calculated by Gensini score (r = 0.40 and P < 0.050). After adjusting confounders, multiple linear regression analysis showed ANA remained independently associated with Gensini scores in ACS group (B = 0.505, P < 0.001).

Conclusion: Higher serum levels of ANA may be considered as independent risk factors for ACS.

Keywords: Acute Coronary Syndrome; Anti-Nuclear Antibodies; Chronic Stable Angina; Gensini Score; Rheumatoid Factor.

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Figures

Figure 1
Figure 1
Linear regression analysis to demonstrate relationship between anti-nuclear antibodies and (log transformed) Gensini scores ACS: Acute coronary syndrome; CSA: Chronic stable angina; ANA: Anti-nuclear antibodies
See this image and copyright information in PMC

References

    1. Yusuf S, Reddy S, Ounpuu S, Anand S. Global burden of cardiovascular diseases: part I: general considerations, the epidemiologic transition, risk factors, and impact of urbanization. Circulation. 2001;104(22):2746–53. - PubMed
    1. Buttar HS, Li T, Ravi N. Prevention of cardiovascular diseases: Role of exercise, dietary interventions, obesity and smoking cessation. Exp Clin Cardiol. 2005;10(4):229–49. - PMC - PubMed
    1. Getz GS, Vanderlaan PA, Reardon CA. The immune system and murine atherosclerosis. Curr Drug Targets. 2007;8(12):1297–306. - PubMed
    1. Ridker PM, Hennekens CH, Buring JE, Rifai N. C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women. N Engl J Med. 2000;342(12):836–43. - PubMed
    1. Liuzzo G, Biasucci LM, Gallimore JR, Grillo RL, Rebuzzi AG, Pepys MB, et al. The prognostic value of C-reactive protein and serum amyloid a protein in severe unstable angina. N Engl J Med. 1994;331(7):417–24. - PubMed

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