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. 2015:2015:506251.
doi: 10.1155/2015/506251. Epub 2015 Feb 26.

Descemet membrane endothelial keratoplasty: intraoperative and postoperative imaging spectral-domain optical coherence tomography

Marcus Ang  1 , Adam M Dubis  2 , Mark R Wilkins  2
Affiliations

Descemet membrane endothelial keratoplasty: intraoperative and postoperative imaging spectral-domain optical coherence tomography

Marcus Ang et al. Case Rep Ophthalmol Med. 2015.

Abstract

We describe a case report of using the same handheld spectral-domain anterior segment optical coherence tomography (ASOCT) for rapid intraoperative and postoperative imaging in a case of Descemet membrane endothelial keratoplasty (DMEK). A 67-year-old woman, with Fuchs dystrophy and corneal decompensation, underwent DMEK with intraoperative ASOCT imaging using the handheld Envisu spectral domain ASOCT system (Bioptigen, Inc., Morrisville, NC, USA). We found that this easy-to-use portable system with handheld probe allowed for rapid imaging of the anterior segment during donor manipulation to visualize the orientation of the DMEK donor, as well as to confirm the initial adhesion of the DMEK donor. Moreover, the same system may be used for postoperative monitoring of graft adhesion, corneal thickness, and stromal remodeling in the clinic with very high-definition images.

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Figures

Figure 1
Figure 1
Anterior segment optical coherence tomography (ASOCT) system with handheld probe and cornea adaptation lens.
Figure 2
Figure 2
Anterior segment optical coherence tomography (ASOCT) images during and after Descemet membrane endothelial keratoplasty (DMEK). (a) Intraoperative ASOCT demonstrating single scroll configuration of DMEK donor seen in the anterior chamber. (b) Intraoperative ASOCT showing initial adhesion. (c) Two hours after DMEK showing early adhesion of DMEK donor with small amount of interface fluid. (d) One day after DMEK with further adhesion of donor graft. (e) One week after DMEK demonstrating reepithelization and thinning of central cornea. (f) One month after DMEK showing complete DMEK donor adhesion with remodeling of cornea stroma and further reduction in edema.
See this image and copyright information in PMC

References

    1. Price M. O., Price F. W. Endothelial keratoplasty—a review. Clinical and Experimental Ophthalmology. 2010;38(2):128–140. doi: 10.1111/j.1442-9071.2010.02213.x. - DOI - PubMed
    1. Lee W. B., Jacobs D. S., Musch D. C., Kaufman S. C., Reinhart W. J., Shtein R. M. Descemet's stripping endothelial keratoplasty: safety and outcomes: a report by the American Academy of Ophthalmology. Ophthalmology. 2009;116(9):1818–1830. doi: 10.1016/j.ophtha.2009.06.021. - DOI - PubMed
    1. Monnereau C., Quilendrino R., Dapena I., et al. Multicenter study of descemet membrane endothelial keratoplasty: first case series of 18 surgeons. JAMA Ophthalmology. 2014;132(10):1192–1198. doi: 10.1001/jamaophthalmol.2014.1710. - DOI - PubMed
    1. Anshu A., Price M. O., Price F. W., Jr. Risk of corneal transplant rejection significantly reduced with Descemet's membrane endothelial keratoplasty. Ophthalmology. 2012;119(3):536–540. doi: 10.1016/j.ophtha.2011.09.019. - DOI - PubMed
    1. Guerra F. P., Anshu A., Price M. O., Price F. W. Endothelial keratoplasty: fellow eyes comparison of descemet stripping automated endothelial keratoplasty and descemet membrane endothelial keratoplasty. Cornea. 2011;30(12):1382–1386. doi: 10.1097/ico.0b013e31821ddd25. - DOI - PubMed

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