Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2015:2015:641913.
doi: 10.1155/2015/641913. Epub 2015 Mar 1.

HIV-associated neurocognitive disorders: the relationship of HIV infection with physical and social comorbidities

Ellen M Tedaldi  1 , Nancy L Minniti  2 , Tracy Fischer  3
Affiliations
Review

HIV-associated neurocognitive disorders: the relationship of HIV infection with physical and social comorbidities

Ellen M Tedaldi et al. Biomed Res Int. 2015.

Abstract

The prevalence of HIV (human immunodeficiency virus) associated neurocognitive disorders (HAND) will undoubtedly increase with the improved longevity of HIV-infected persons. HIV infection, itself, as well as multiple physiologic and psychosocial factors can contribute to cognitive impairment and neurologic complications. These comorbidities confound the diagnosis, assessment, and interventions for neurocognitive disorders. In this review, we discuss the role of several key comorbid factors that may contribute significantly to the development and progression of HIV-related neurocognitive impairment, as well as the current status of diagnostic strategies aimed at identifying HIV-infected individuals with impaired cognition and future research priorities and challenges.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Neurocognitive disorders: role of HIV infection, comorbidities, and assessments.
See this image and copyright information in PMC

References

    1. Antinori A., Arendt G., Becker J. T., et al. Updated research nosology for HIV-associated neurocognitive disorders. Neurology. 2007;69(18):1789–1799. doi: 10.1212/01.WNL.0000287431.88658.8b. - DOI - PMC - PubMed
    1. Association A. P. Diagnostic and Statistical Manual of Mental Disorders. 5th. Arlington, Va, USA: American Psychiatric Association; 2013.
    1. Becker J. T., Kingsley L., Mullen J., et al. Vascular risk factors, HIV serostatus, and cognitive dysfunction in gay and bisexual men. Neurology. 2009;73(16):1292–1299. doi: 10.1212/WNL.0b013e3181bd10e7. - DOI - PMC - PubMed
    1. Bonnet F., Amieva H., Marquant F., et al. Cognitive disorders in HIV-infected patients: are they HIV-related? AIDS. 2013;27(3):391–400. doi: 10.1097/qad.0b013e32835b1019. - DOI - PubMed
    1. Crystal H. A., Weedon J., Holman S., et al. Associations of cardiovascular variables and HAART with cognition in middle-aged HIV-infected and uninfected women. Journal of NeuroVirology. 2011;17(5):469–476. doi: 10.1007/s13365-011-0052-3. - DOI - PMC - PubMed

Publication types

MeSH terms

LinkOut - more resources