Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2013:2013:906467.
doi: 10.1155/2013/906467. Epub 2013 Apr 4.

Temporal trends in chorioamnionitis by maternal race/ethnicity and gestational age (1995-2010)

Michael J Fassett  1 , Deborah A Wing  2 , Darios Getahun  3
Affiliations

Temporal trends in chorioamnionitis by maternal race/ethnicity and gestational age (1995-2010)

Michael J Fassett et al. Int J Reprod Med. 2013.

Abstract

Objective. To characterize trends in chorioamnionitis (CAM) by maternal race/ethnicity and gestational age. Study Design. We examined trends in CAM from 1995-2010 among singleton births in all Kaiser Permanente Southern California hospitals (n = 471,821). Data were extracted from Perinatal Service System and clinical utilization records. Gestational age- and race/ethnicity-specific biannual diagnosis rates were estimated using the Poisson regression after adjusting for potential confounding factors. Results. Overall diagnosis rates of CAM increased from 2.7% in 1995-1996 to 6.0% in 2009-2010 with a relative increase of 126% (95% confidence intervals [CI] 113%-149%). From 1995-1996 to 2009-2010, CAM increased among the Whites (1.8% to 4.3%, P-value for trend <.001), Blacks (2.2% to 3.7%, P-value for trend <.001), Hispanics (2.4% to 5.8%, P-value for trend <.001), and Asian/Pacific Islanders (3.6% to 9.0%, P-value for trend <.001). The adjusted relative percentage change in CAM from 1995-1996 to 2009-2010 was for Whites [preterm 21% (9%-78%), term 138% (108%-173%)], for Blacks [preterm 24% (-9%-81%), term 62% (30%-101%)], for Hispanics [preterm 31% (3%-66%), term 135% (114%-159%)], and for Asian/Pacific Islanders [preterm 44% (9%-127%), term 145% (109%-188%)]. Conclusion. The findings suggest that CAM diagnosis rate has increased for all race/ethnic groups. This increase is primarily due to increased diagnosis at term gestation.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Race/ethnic disparity in rates of chorioamnionitis (CAM). ∗Adjustments were made for maternal age, education, median household income, parity, prenatal care, smoking during pregnancy, and induction of labor.
Figure 2
Figure 2
Temporal trends in the rate of chorioamnionitis (CAM) based on induction of labor subtypes. IOL: induction of labor. ∗Adjustments were made for maternal age, race/ethnicity, education, median household income, parity, prenatal care, and smoking during pregnancy.
See this image and copyright information in PMC

References

    1. Gibbs RS, Duff P. Progress in pathogenesis and management of clinical intraamniotic infection. American Journal of Obstetrics and Gynecology. 1991;164(5):1317–1326. - PubMed
    1. Getahun D, Strickland D, Zeiger RS, et al. Effect of chorioamnionitis on early childhood asthma. Archives of Pediatrics & Adolescent Medicine. 2010;164(2):187–192. - PubMed
    1. Getahun D, Ananth CV, Kinzler WL. Risk factors for antepartum and intrapartum stillbirth: a population-based study. American Journal of Obstetrics and Gynecology. 2007;196(6):499–507. - PubMed
    1. Tasci Y, Dilbaz B, Uzmez Onal B, et al. The value of cord blood interleukin-6 levels for predicting chorioamnionitis, funisitis and neonatal infection in term premature rupture of membranes. European Journal of Obstetrics, Gynecology, and Reproductive Biology. 2006;128:34–39. - PubMed
    1. Marret S, Ancel PY, Marpeau L, et al. Neonatal and 5-year outcomes after birth at 30-34 weeks of gestation. Obstetrics and Gynecology. 2007;110(1):72–80. - PubMed