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. 2015 Mar 25;13(4):1698-709.
doi: 10.3390/md13041698.

Identification and bioactivity of compounds from the fungus Penicillium sp. CYE-87 isolated from a marine tunicate

Lamiaa A Shaala  1   2 , Diaa T A Youssef  3
Affiliations

Identification and bioactivity of compounds from the fungus Penicillium sp. CYE-87 isolated from a marine tunicate

Lamiaa A Shaala et al. Mar Drugs. .

Abstract

In the course of our continuous interest in identifying bioactive compounds from marine microbes, we have investigated a tunicate-derived fungus, Penicillium sp. CYE-87. A new compound with the 1,4-diazepane skeleton, terretrione D (2), together with the known compounds, methyl-2-([2-(1H-indol-3-yl)ethyl]carbamoyl)acetate (1), tryptamine (3), indole-3-carbaldehyde (4), 3,6-diisobutylpyrazin-2(1H)-one (5) and terretrione C (6), were isolated from Penicillium sp. CYE-87. The structures of the isolated compounds were established by spectral analysis, including 1D (1H, 13C) and 2D (COSY, multiplicity edited-HSQC and HMBC) NMR and HRESIMS, as well as comparison of their NMR data with those in the literature. The compounds were evaluated for their antimigratory activity against the human breast cancer cell line (MDA-MB-231) and their antiproliferation activity against HeLa cells. Compounds 2 and 6 showed significant antimigratory activity against MDA-MB-231, as well as antifungal activity against C. albicans.

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Figures

Figure 1
Figure 1
Structures of Compounds 1–6.
Figure 2
Figure 2
Key COSY and HMBC correlations of 2.
Figure 3
Figure 3
Important H-3 and H-6 NOESY correlation in 2.
See this image and copyright information in PMC

References

    1. Newman D.J., Cragg G.M. Natural products as sources of new drugs over the 30 years from 1981 to 2010. J. Nat. Prod. 2012;75:311–335. doi: 10.1021/np200906s. - DOI - PMC - PubMed
    1. Harvey A.L. Natural products in drug discovery. Drug Discov. Today. 2008;13:894–901. doi: 10.1016/j.drudis.2008.07.004. - DOI - PubMed
    1. Blunt J.W., Copp B.R., Keyzers R.A., Munro M.H.G., Prinsep M.R. Marine natural products. Nat. Prod. Rep. 2012;29:144–222. doi: 10.1039/C2NP00090C. - DOI - PubMed
    1. Blunt J.W., Copp B.R., Munro M.H.G., Northcote P.T., Prinsep M.R. Marine natural products. Nat. Prod. Rep. 2010;27:165–237. doi: 10.1039/b906091j. - DOI - PubMed
    1. Imhoff J.F., Stöhr R. Sponge-associated bacteria: General overview and special aspects of bacteria associated with Halichondria panicea. Prog. Mol. Subcell. Biol. 2003;37:35–57. - PubMed

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