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. 2015 Mar 27;10(3):e0121119.
doi: 10.1371/journal.pone.0121119. eCollection 2015.

Retinal vascular fractal dimension, childhood IQ, and cognitive ability in old age: the Lothian Birth Cohort Study 1936

Adele M Taylor  1 , Thomas J MacGillivray  2 , Ross D Henderson  1 , Lasma Ilzina  1 , Baljean Dhillon  3 , John M Starr  4 , Ian J Deary  5
Affiliations

Retinal vascular fractal dimension, childhood IQ, and cognitive ability in old age: the Lothian Birth Cohort Study 1936

Adele M Taylor et al. PLoS One. .

Abstract

Purpose: Cerebral microvascular disease is associated with dementia. Differences in the topography of the retinal vascular network may be a marker for cerebrovascular disease. The association between cerebral microvascular state and non-pathological cognitive ageing is less clear, particularly because studies are rarely able to adjust for pre-morbid cognitive ability level. We measured retinal vascular fractal dimension (Df) as a potential marker of cerebral microvascular disease. We examined the extent to which it contributes to differences in non-pathological cognitive ability in old age, after adjusting for childhood mental ability.

Methods: Participants from the Lothian Birth Cohort 1936 Study (LBC1936) had cognitive ability assessments and retinal photographs taken of both eyes aged around 73 years (n = 648). IQ scores were available from childhood. Retinal vascular Df was calculated with monofractal and multifractal analysis, performed on custom-written software. Multiple regression models were applied to determine associations between retinal vascular Df and general cognitive ability (g), processing speed, and memory.

Results: Only three out of 24 comparisons (two eyes × four Df parameters × three cognitive measures) were found to be significant. This is little more than would be expected by chance. No single association was verified by an equivalent association in the contralateral eye.

Conclusions: The results show little evidence that fractal measures of retinal vascular differences are associated with non-pathological cognitive ageing.

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Conflict of interest statement

Competing Interests: The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. Flow diagram of exclusion factors associated with the study population.
Fig 2
Fig 2. Colour retinal image acquired by fundus photography and retinal blood vessels segmented by computerized procedure.
See this image and copyright information in PMC

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