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. 1985 May 30;845(2):249-53.
doi: 10.1016/0167-4889(85)90183-1.

HeLa cells have histamine H1-receptors which mediate activation of the K+ conductance

A Hazama, T Yada, Y Okada

HeLa cells have histamine H1-receptors which mediate activation of the K+ conductance

A Hazama et al. Biochim Biophys Acta. .

Abstract

HeLa cells responded to exogenous histamine with a transient hyperpolarization due to increased membrane conductance to K+. After successive applications of histamine, the cell membrane became virtually unresponsive (desensitized). The responses were blocked by pyrilamine but not by cimetidine. Thus, it appears that HeLa cells have H1-receptors which mediate an increase in the K+ conductance.

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