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. 2015;10(5):753-63.
doi: 10.2217/nnm.14.228.

Active implant combining human stem cell microtissues and growth factors for bone-regenerative nanomedicine

Jessica Schiavi  1 , Laetitia Keller, David-Nicolas Morand, Natalia De Isla, Olivier Huck, Jean Christophe Lutz, Didier Mainard, Pascale Schwinté, Nadia Benkirane-Jessel
Affiliations

Active implant combining human stem cell microtissues and growth factors for bone-regenerative nanomedicine

Jessica Schiavi et al. Nanomedicine (Lond). 2015.

Erratum in

  • Erratum.
    [No authors listed] [No authors listed] Nanomedicine (Lond). 2016;11(5):567. doi: 10.2217/nnm.16.12. Epub 2016 Feb 19. Nanomedicine (Lond). 2016. PMID: 26892150 No abstract available.

Abstract

Aims: Mesenchymal stem cells (MSCs) from adult bone marrow provide an exciting and promising stem cell population for the repair of bone in skeletal diseases. Here, we describe a new generation of collagen nanofiber implant functionalized with growth factor BMP-7 nanoreservoirs and equipped with human MSC microtissues (MTs) for regenerative nanomedicine.

Materials & methods: By using a 3D nanofibrous collagen membrane and by adding MTs rather than single cells, we optimize the microenvironment for cell colonization, differentiation and growth.

Results & conclusion: Furthermore, in this study, we have shown that by combining BMP-7 with these MSC MTs in this double 3D environment, we further accelerate bone growth in vivo. The strategy described here should enhance the efficiency of therapeutic implants compared with current simplistic approaches used in the clinic today based on collagen implants soaked in bone morphogenic proteins.

Keywords: BMP-7; bone regeneration; collagen nanofibers implant; human mesenchymal stem cells; microtissues; regenerative nanomedicine.

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