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. 1985 Jun;93(1):38-45.
doi: 10.1016/0008-8749(85)90386-7.

Recombinant interleukin 2 rapidly augments human natural killer cell activity

D Kabelitz, H Kirchner, D Armerding, H Wagner

Recombinant interleukin 2 rapidly augments human natural killer cell activity

D Kabelitz et al. Cell Immunol. 1985 Jun.

Abstract

Recombinant human interleukin 2 (r-IL-2) rapidly stimulated human natural killer cell activity in vitro. Augmentation of NK activity occurred within 1 hr of preincubation with r-IL-2. Responsive killer cells were typical NK cells as shown by cell fractionation procedures. These included Percoll density gradient separation and depletion of OKT3+ T cells by an indirect rosetting method. Analysis with a panel of polyclonal and monoclonal antibodies against alpha and gamma interferon revealed that this early enhancement of NK activity by r-IL-2 was independent of the production of both types of interferon.

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