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Multicenter Study
. 2015 Nov:151:18-25.
doi: 10.1016/j.mad.2015.03.007. Epub 2015 Mar 26.

MARK-AGE standard operating procedures (SOPs): A successful effort

María Moreno-Villanueva  1 , Miriam Capri  2 , Nicolle Breusing  3 , Anne Siepelmeyer  4 , Federica Sevini  2 , Alessandro Ghezzo  5 , Anton J M de Craen  6 , Antti Hervonen  7 , Mikko Hurme  7 , Christiane Schön  4 , Tilman Grune  8 , Claudio Franceschi  2 , Alexander Bürkle  9
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Free article
Multicenter Study

MARK-AGE standard operating procedures (SOPs): A successful effort

María Moreno-Villanueva et al. Mech Ageing Dev. 2015 Nov.
Free article

Abstract

Within the MARK-AGE project, a population study (3337 subjects) was conducted to identify a set of biomarkers of ageing which, as a combination of parameters with appropriate weighting, would measure biological age better than any single marker. The MARK-AGE project involves 14 European countries and a total of 26 research centres. In such a study, standard operating procedures (SOPs) are an essential task, which are binding for all MARK-AGE Beneficiaries. The SOPs cover all aspects of subject's recruitment, collection, shipment and distribution of biological samples (blood and its components, buccal mucosa cells or BMC and urine) as well as the anthropometric measurements and questionnaires.

Keywords: Biobank; Human studies; Standard operating procedures.

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