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Comparative Study
. 2015 Mar 27:8:27048.
doi: 10.3402/gha.v8.27048. eCollection 2015.

Outcome of tuberculosis treatment in HIV-positive adults diagnosed through active versus passive case-finding

Taye T Balcha  1   2 , Sten Skogmar  1 , Erik Sturegård  3 , Per Björkman  1 , Niclas Winqvist  1   4
Affiliations
Comparative Study

Outcome of tuberculosis treatment in HIV-positive adults diagnosed through active versus passive case-finding

Taye T Balcha et al. Glob Health Action. .

Abstract

Background: The World Health Organization strongly recommends regular screening for tuberculosis (TB) in HIV-positive individuals.

Objective: To compare the outcome of anti-tuberculosis treatment (ATT) in HIV-positive adults diagnosed with TB through active case-finding (ACF) or passive case-finding (PCF).

Design: Antiretroviral therapy (ART)-naïve adults diagnosed with TB were included from two prospective cohort studies conducted in Ethiopia between September 2010 and March 2013. The PCF cohort was based at out-patient TB clinics, whereas participants in the ACF cohort were actively screened for TB by bacteriological sputum testing (smear microscopy, Xpert MTB/RIF assay, and liquid culture) without pre-selection on the basis of symptoms and signs. Outcomes of ATT were compared between participants in the two cohorts; characteristics at diagnosis and predictors of adverse outcomes were analysed.

Results: Among 439 TB/HIV co-infected participants, 307 and 132 belonged to PCF and ACF cohorts, respectively. Compared with the ACF participants, hemoptysis, conjunctival pallor, bedridden status, and low mid upper-arm circumference (MUAC) were significantly more common in participants identified through PCF. Sputum smear-positivity rates among pulmonary TB cases were 44.2% and 21.1% in the PCF and ACF cohorts, respectively (p<0.001). Treatment success was ascertained in 247 (80.5%) of the participants in the PCF cohort and 102 (77.2%) of the participants in the ACF cohorts (p=0.223). Low MUAC (p=0.001) independently predicted mortality in the participants in both cohorts.

Conclusion: Although patients identified through ACF had less advanced TB disease, ATT outcome was similar to the patients identified through PCF. To achieve a better outcome, case management in ACF strategy should be strengthened through enhanced patient-centred counselling and adherence support.

Keywords: HIV; TB; active case-finding; adverse treatment outcomes; passive case-finding.

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