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. 2015 Feb;32(1):21-6.
doi: 10.5114/pdia.2014.40957. Epub 2015 Feb 3.

The effect of clary sage oil on staphylococci responsible for wound infections

Monika Sienkiewicz  1 , Anna Głowacka  1 , Katarzyna Poznańska-Kurowska  2 , Andrzej Kaszuba  2 , Anna Urbaniak  3 , Edward Kowalczyk  3
Affiliations

The effect of clary sage oil on staphylococci responsible for wound infections

Monika Sienkiewicz et al. Postepy Dermatol Alergol. 2015 Feb.

Abstract

Introduction: The spreading of bacterial antibiotic resistance among clinical strains of pathogenic bacteria has made investigators to search for other active antibacterial agents which could provide a valuable complement to the existing therapies.

Aim: To determine the antibacterial activity of clary sage oil (Salvia sclarea L.) against Staphylococcus clinical strains which were isolated from patients with wound infections.

Material and methods: A comprehensive evaluation of Staphylococcus clinical strain resistance to antibiotics was performed. The constituents of clary sage oil were assayed by GC-FID-MS analysis. The minimal inhibitory concentration (MIC) of the tested essential oil against staphylococci by the micro-dilution broth method was determined.

Results: The clary sage oil was active against Staphylococcus aureus, S. epidermidis and S. xylosus with MIC values ranging from 3.75 to 7.00 µl/ml.

Conclusions: The results of the in vitro tests encourage to use formulations containing sage oil as the active natural antimicrobial agent. Because of its antimicrobial properties clary sage oil may be applied to treat wounds and skin infections.

Keywords: Staphylococcus; clary sage oil; minimal inhibitory concentration; wounds.

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Figures

Figure 1
Figure 1
Staphylococcus clinical strains isolated from wounds resistant to recommended antibiotics
Figure 2
Figure 2
The activity of clary sage oil against Staphylococcus clinical strains isolated from wounds
See this image and copyright information in PMC

References

    1. DeLeo FR, Otto M, Kreiswirth BN, Chambers HN. Community-associated methicillinresistant Staphylococcus aureus. Lancet. 2010;375:1557–68. - PMC - PubMed
    1. Boers SA, van Ess I, Euser SM, et al. An outbreak of a multiresistant methicillin-susceptible Staphylococcus aureus (MR-MSSA) strain in a burn centre: the importance of routine molecular typing. Burns. 2011;37:808–13. - PubMed
    1. Valencia IC, Kirsner RS, Kerdel FA. Microbiologic evaluation of skin wounds: alarming trend toward antibiotic resistance in an inpatient dermatology service during a 10-year period. J Am Acad Dermatol. 2004;50:845–9. - PubMed
    1. Edwards R, Harding KG. Bacteria and wound healing. Curr Opin Infect Dis. 2004;17:91–6. - PubMed
    1. Higaki S, Kitagawa T, Kagoura M, et al. Predominant Staphylococcus aureus isolated from various skin diseases. J Int Med Res. 2000;28:187–90. - PubMed