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. 2015:2015:142129.
doi: 10.1155/2015/142129. Epub 2015 Mar 3.

Electroacupuncture Treatment Improves Learning-Memory Ability and Brain Glucose Metabolism in a Mouse Model of Alzheimer's Disease: Using Morris Water Maze and Micro-PET

Jing Jiang  1 , Kai Gao  2 , Yuan Zhou  1 , Anping Xu  1 , Suhua Shi  1 , Gang Liu  3 , Zhigang Li  1
Affiliations

Electroacupuncture Treatment Improves Learning-Memory Ability and Brain Glucose Metabolism in a Mouse Model of Alzheimer's Disease: Using Morris Water Maze and Micro-PET

Jing Jiang et al. Evid Based Complement Alternat Med. 2015.

Abstract

Introduction. Alzheimer's disease (AD) causes progressive hippocampus dysfunctions leading to the impairment of learning and memory ability and low level of uptake rate of glucose in hippocampus. What is more, there is no effective treatment for AD. In this study, we evaluated the beneficial and protective effects of electroacupuncture in senescence-accelerated mouse prone 8 (SAMP8). Method. In the electroacupuncture paradigm, electroacupuncture treatment was performed once a day for 15 days on 7.5-month-old SAMP8 male mice. In the normal control paradigm and AD control group, 7.5-month-old SAMR1 male mice and SAMP8 male mice were grabbed and bandaged while electroacupuncture group therapy, in order to ensure the same treatment conditions, once a day, 15 days. Results. From the Morris water maze (MWM) test, we found that the treatment of electroacupuncture can improve the spatial learning and memory ability of SAMP8 mouse, and from the micro-PET test, we proved that after the electroacupuncture treatment the level of uptake rate of glucose in hippocampus was higher than normal control group. Conclusion. These results suggest that the treatment of electroacupuncture may provide a viable treatment option for AD.

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Figures

Figure 1
Figure 1
(a) Comparison of the escape latency of all groups. (b) The trend of the escape latency of all groups. (c) Comparison the mean of the escape latency of all groups.
Figure 2
Figure 2
(a) The percentage of time spent in platform quadrant of each group. (b) The percentage of time spent in platform quadrant of each group.
Figure 3
Figure 3
Right side hippocampus of the mice in micro-PET scan image. (a) Normal control group; (b) Alzheimer's disease group; (c) electroacupuncture treatment group. Color code: min = 0, max = 6.
Figure 4
Figure 4
(a) The uptake rate of 18F-FDG per gram in hippocampus. (b) The uptake rate of 18F-FDG per gram in hippocampus.
See this image and copyright information in PMC

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