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. 2015:2015:903603.
doi: 10.1155/2015/903603. Epub 2015 Mar 2.

Inhibitory effects of sodium arsenite and acacia honey on acetylcholinesterase in rats

Aliyu Muhammad  1 , Oyeronke A Odunola  2 , Michael A Gbadegesin  2 , Abdullahi B Sallau  3 , Uche S Ndidi  3 , Mohammed A Ibrahim  3
Affiliations

Inhibitory effects of sodium arsenite and acacia honey on acetylcholinesterase in rats

Aliyu Muhammad et al. Int J Alzheimers Dis. 2015.

Abstract

This study was conducted to investigate the effect of sodium arsenite and Acacia honey on acetylcholinesterase (AChE) activity and electrolytes in the brain and serum of Wistar rats. Male Wistar albino rats in four groups of five rats each were treated with distilled water, sodium arsenite (5 mg/kg body weight), Acacia honey (20% v/v), and sodium arsenite and Acacia honey, daily for one week. The sodium arsenite and Acacia honey significantly (P < 0.05) decreased AChE activity in the brain with the combined treatment being more potent. Furthermore, sodium arsenite and Acacia honey significantly (P < 0.05) decreased AChE activity in the serum. Strong correlation was observed between the sodium and calcium ion levels with acetylcholinesterase activity in the brain and serum. The gas chromatography mass spectrometry analysis of Acacia honey revealed the presence of a number of bioactive compounds such as phenolics, sugar derivatives, and fatty acids. These findings suggest that sodium arsenite and/or Acacia honey modulates acetylcholinesterase activities which may be explored in the management of Alzheimer's diseases but this might be counteracted by the hepatotoxicity induced by arsenics.

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Figures

Figure 1
Figure 1
The effect of sodium arsenite on the activity of acetylcholinesterase in vitro. Values are presented as mean ± SD.
Figure 2
Figure 2
The effect of Acacia honey on the activity of acetylcholinesterase in vitro. Values are presented as mean ± SD.
Figure 3
Figure 3
GC-MS analysis results of Acacia honey.
Figure 4
Figure 4
The vitamin and mineral contents of Acacia honey. The mineral element contents of Acacia honey. Values are presented as mean ± SD.
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