Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2015:2015:329792.
doi: 10.1155/2015/329792. Epub 2015 Mar 2.

Serum levels of proinflammatory cytokines in painful knee osteoarthritis and sensitization

Marta Imamura  1 , Fernando Ezquerro  2 , Fábio Marcon Alfieri  3 , Lucy Vilas Boas  4 , Tania Regina Tozetto-Mendoza  4 , Janini Chen  5 , Levent Özçakar  6 , Lars Arendt-Nielsen  7 , Linamara Rizzo Battistella  1
Affiliations

Serum levels of proinflammatory cytokines in painful knee osteoarthritis and sensitization

Marta Imamura et al. Int J Inflam. 2015.

Abstract

Osteoarthritis (OA) is the most common joint disorder in the world. Among the mechanisms involved in osteoarthritis, biomarkers (cytokines profile) may be related to pain and pain intensity, functional capacity, and pressure pain thresholds (PPT). Thus, the study of these relationships may offer useful information about pathophysiology and associated mechanisms involved in osteoarthritis. Therefore, the objective of this study was to investigate the seric concentration of pro (IL-6, IL-8, and TNF-α) and anti-inflammatory (IL-10) cytokines in patients with painful knee osteoarthritis and to correlate the levels of these biomarkers with the patients' functional capacity and pressure pain threshold (PPT) values.

PubMed Disclaimer

References

    1. Alkan B. M., Fidan F., Tosun A., Ardiçoğlu Ö. Quality of life and self-reported disability in patients with knee osteoarthritis. Modern Rheumatology. 2014;24(1):166–171. doi: 10.1007/s10165-013-0844-9. - DOI - PubMed
    1. Kotlarz H., Gunnarsson C. L., Fang H., Rizzo J. A. Insurer and out-of-pocket costs of osteoarthritis in the US: evidence from national survey data. Arthritis and Rheumatism. 2009;60(12):3546–3553. doi: 10.1002/art.24984. - DOI - PubMed
    1. Ang D. C., James G., Stump T. E. Clinical appropriateness and not race predicted referral for joint arthroplasty. Arthritis Care and Research. 2009;61(12):1677–1685. doi: 10.1002/art.24944. - DOI - PMC - PubMed
    1. Fellet A. J., Afonso A. F., Barbosa L. F. Osteoarthrosis: uma revisão. Revista Brasileira de Medicina. 2007;64(11):55–61.
    1. Zhang W., Nuki G., Moskowitz R. W., et al. OARSI recommendations for the management of hip and knee osteoarthritis. Part III: changes in evidence following systematic cumulative update of research published through January 2009. Osteoarthritis and Cartilage. 2010;18(4):476–499. doi: 10.1016/j.joca.2010.01.013. - DOI - PubMed

LinkOut - more resources