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Review
. 2015 Mar 10;6(2):109-20.
doi: 10.14336/AD.2014.0305. eCollection 2015 Mar.

Metabolic syndrome, aging and involvement of oxidative stress

Francesca Bonomini  1 , Luigi Fabrizio Rodella  1 , Rita Rezzani  1
Affiliations
Review

Metabolic syndrome, aging and involvement of oxidative stress

Francesca Bonomini et al. Aging Dis. .

Abstract

The prevalence of the metabolic syndrome, a cluster of cardiovascular risk factors associated with obesity and insulin resistance, is dramatically increasing in Western and developing countries. This disorder consists of a cluster of metabolic conditions, such as hypertriglyceridemia, hyper-low-density lipoproteins, hypo-high-density lipoproteins, insulin resistance, abnormal glucose tolerance and hypertension, that-in combination with genetic susceptibility and abdominal obesity-are risk factors for type 2 diabetes, vascular inflammation, atherosclerosis, and renal, liver and heart diseases. One of the defects in metabolic syndrome and its associated diseases is excess of reactive oxygen species. Reactive oxygen species generated by mitochondria, or from other sites within or outside the cell, cause damage to mitochondrial components and initiate degradative processes. Such toxic reactions contribute significantly to the aging process. In this article we review current understandings of oxidative stress in metabolic syndrome related disease and its possible contribution to accelerated senescence.

Keywords: accelerated senescence; aging; metabolic syndrome; oxidative stress.

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Figures

Figure 1.
Figure 1.
Schematic relationship between ROS production, accelerated senescence and metabolic syndrome.
See this image and copyright information in PMC

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