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. 2015:2015:646853.
doi: 10.1155/2015/646853. Epub 2015 Mar 3.

Expression of MMP-9 and VEGF in meningiomas and their correlation with peritumoral brain edema

Joanna Reszec  1 , Adam Hermanowicz  2 , Robert Rutkowski  2 , Grzegorz Turek  2 , Zenon Mariak  2 , Lech Chyczewski  1
Affiliations

Expression of MMP-9 and VEGF in meningiomas and their correlation with peritumoral brain edema

Joanna Reszec et al. Biomed Res Int. 2015.

Abstract

Meningiomas constitute up to 13% of all intracranial tumors. The predictive factors for meningioma have not been unambiguously defined; however some limited data suggest that the expression of matrix metalloproteinases (MMPs) and vascular endothelial growth factor (VEGF) may be associated with the presence of peritumoral brain edema (PTBE) and worse clinical outcome. The aim of this study was to analyze the expressions of MMP-9 and VEGF in a group of meningiomas of various grades and to study associations between these two markers and PTBE. The study included patients with supratentorial meningiomas. The patients were divided into low- (G1) and high-grade meningiomas (G2 and G3). PTBE was assessed on MRI. The expressions of VEGF and MMP-9 were determined immunohistochemically. The expression of MMP-9 was observed significantly more often in G3 meningiomas than in lower grade tumors. The presence of stage II or III PTBE was associated with a significant increase in MMP-9 expression. The expression of VEGF did not differ across the PTBE stages. Our findings point to a significant role of MMP-9 and VEGF in the pathogenesis of peritumoral brain edema in low- and high-grade meningiomas.

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Figures

Figure 1
Figure 1
(a) A significant MMP-9 expression in anaplastic meningioma with PTBE III°. Magnification 400x. ((b), (c)) Strong (b) and weak (c) MMP-9 expression in atypical meningioma. Magnifications 200x and 400x. (d) MMP-9 expression in mixed type of low-grade meningioma. Magnification 200x.
Figure 2
Figure 2
(a) VEGF expression in high-grade meningioma. Magnification 200x. (b) Strong VEGF expression in angiomatous low-grade meningioma. Magnification 400x. (c) VEGF expression in atypical meningioma with peritumoral brain edema II°. Magnification 200x. (d) Mixed type of meningioma with significant VEGF expression and presence of PTBE. Magnification 100x.
Figure 3
Figure 3
(a)–(d) MRI scans show transitional meningioma (G1) with peritumoral brain edema III°.
See this image and copyright information in PMC

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