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Review
. 2015 Apr;31(2):235-41.
doi: 10.1007/s12264-014-1506-4. Epub 2015 Mar 31.

Prefrontal dysfunction and a monkey model of schizophrenia

Ping Mao  1 , Ding Cui, Xu-Dong Zhao, Yuan-Ye Ma
Affiliations
Review

Prefrontal dysfunction and a monkey model of schizophrenia

Ping Mao et al. Neurosci Bull. 2015 Apr.

Abstract

The prefrontal cortex is implicated in cognitive functioning and schizophrenia. Prefrontal dysfunction is closely associated with the symptoms of schizophrenia. In addition to the features typical of schizophrenia, patients also present with aspects of cognitive disorders. Based on these relationships, a monkey model mimicking the cognitive symptoms of schizophrenia has been made using treatment with the non-specific competitive N-methyl-D-aspartate receptor antagonist, phencyclidine. The symptoms are ameliorated by atypical antipsychotic drugs such as clozapine. The beneficial effects of clozapine on behavioral impairment might be a specific indicator of schizophrenia-related cognitive impairment.

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