. 2015 Mar 31:6:6689.

doi: 10.1038/ncomms7689.

Identification of myopia-associated WNT7B polymorphisms provides insights into the mechanism underlying the development of myopia

Masahiro Miyake^{1

2}, Kenji Yamashiro¹, Yasuharu Tabara², Kenji Suda¹, Satoshi Morooka¹, Hideo Nakanishi¹, Chiea-Chuen Khor^{3

4

5

6}, Peng Chen³, Fan Qiao³, Isao Nakata^{1

2}, Yumiko Akagi-Kurashige^{1

2}, Norimoto Gotoh², Akitaka Tsujikawa¹, Akira Meguro⁷, Sentaro Kusuhara⁸, Ozen Polasek⁹, Caroline Hayward¹⁰, Alan F Wright¹⁰, Harry Campbell¹¹, Andrea J Richardson¹², Maria Schache¹², Masaki Takeuchi^{7

13}, David A Mackey^{12

14}, Alex W Hewitt¹², Gabriel Cuellar¹⁵, Yi Shi¹⁶, Luling Huang¹⁶, Zhenglin Yang^{16

17

18}, Kim Hung Leung¹⁹, Patrick Y P Kao²⁰, Maurice K H Yap²⁰, Shea Ping Yip¹⁹, Muka Moriyama²¹, Kyoko Ohno-Matsui²¹, Nobuhisa Mizuki⁷, Stuart MacGregor¹⁵, Veronique Vitart¹⁰, Tin Aung^{4

22}, Seang-Mei Saw^{3

4

22}, E-Shyong Tai^{3

23

24}, Tien Yin Wong^{4

21

22}, Ching-Yu Cheng^{4

22

24}, Paul N Baird¹², Ryo Yamada², Fumihiko Matsuda²; Nagahama Study Group; Nagahisa Yoshimura¹

Collaborators, Affiliations

Collaborators

Nagahama Study Group:
Takeo Nakayama, Akihiro Sekine, Shinji Kosugi

Affiliations

¹ Department of Ophthalmology and Visual Science, Kyoto University Graduate School of Medicine, Kyoto 6068507, Japan.
² Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto 6068503, Japan.
³ Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore 117597, Singapore.
⁴ Department of Ophthalmology, National University of Singapore and National University Health System, Singapore 119228, Singapore.
⁵ Department of Pediatrics, National University of Singapore, Singapore 119077, Singapore.
⁶ Division of Human Genetics, Genome Institute of Singapore, Singapore 138672, Singapore.
⁷ Department of Ophthalmology and Visual Science, Yokohama City University Graduate School of Medicine, Yokohama 2360027, Japan.
⁸ Division of Ophthalmology, Department of Surgery, Kobe University Graduate School of Medicine, Kobe 6570013, Japan.
⁹ Faculty of Medicine, University of Split, Split 21000, Croatia.
¹⁰ Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH8 9YL, UK.
¹¹ Centre for Population Health Sciences, Medical School, Teviot, Edinburgh EH8 9AG, UK.
¹² Centre for Eye Research Australia (CERA), University of Melbourne, Royal Victorian Eye and Ear Hospital, Melbourne, Victoria 3002, Australia.
¹³ Inflammatory Disease Section, Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.
¹⁴ Centre for Ophthalmology and Visual Science, Lions Eye Institute, University of Western Australia, Perth, Western Australia 6009, Australia.
¹⁵ Statistical Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia.
¹⁶ Sichuan Provincial Key Laboratory for Human Disease Gene Study, Hospital of the University of Electronic Science and Technology of China and Sichuan Provincial People's Hospital, Chengdu, Sichuan 610072, China.
¹⁷ School of Medicine, University of Electronic Science and Technology of China and Sichuan Provincial People's Hospital, Chengdu, Sichuan 610072, China.
¹⁸ Sichuan Translational Medicine Hospital, Chinese Academy of Sciences, Chengdu, Sichuan 610072, China.
¹⁹ Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Hong Kong SAR 99907, China.
²⁰ Centre for Myopia Research, School of Optometry, The Hong Kong Polytechnic University, Hong Kong SAR 99907, China.
²¹ Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University, Tokyo 1130034, Japan.
²² Singapore Eye Research Institute, Singapore National Eye Centre, Singapore 168751, Singapore.
²³ Department of Medicine, National University of Singapore and National University Health System, Singapore 119228, Singapore.
²⁴ Duke-NUS Graduate Medical School, Singapore 169857, Singapore.

PMID: 25823570
DOI: 10.1038/ncomms7689

Free article

Identification of myopia-associated WNT7B polymorphisms provides insights into the mechanism underlying the development of myopia

Masahiro Miyake et al. Nat Commun. 2015.

Free article

. 2015 Mar 31:6:6689.

doi: 10.1038/ncomms7689.

Authors

Collaborators

Nagahama Study Group:
Takeo Nakayama, Akihiro Sekine, Shinji Kosugi

Affiliations

¹ Department of Ophthalmology and Visual Science, Kyoto University Graduate School of Medicine, Kyoto 6068507, Japan.
² Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto 6068503, Japan.
³ Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore 117597, Singapore.
⁴ Department of Ophthalmology, National University of Singapore and National University Health System, Singapore 119228, Singapore.
⁵ Department of Pediatrics, National University of Singapore, Singapore 119077, Singapore.
⁶ Division of Human Genetics, Genome Institute of Singapore, Singapore 138672, Singapore.
⁷ Department of Ophthalmology and Visual Science, Yokohama City University Graduate School of Medicine, Yokohama 2360027, Japan.
⁸ Division of Ophthalmology, Department of Surgery, Kobe University Graduate School of Medicine, Kobe 6570013, Japan.
⁹ Faculty of Medicine, University of Split, Split 21000, Croatia.
¹⁰ Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH8 9YL, UK.
¹¹ Centre for Population Health Sciences, Medical School, Teviot, Edinburgh EH8 9AG, UK.
¹² Centre for Eye Research Australia (CERA), University of Melbourne, Royal Victorian Eye and Ear Hospital, Melbourne, Victoria 3002, Australia.
¹³ Inflammatory Disease Section, Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.
¹⁴ Centre for Ophthalmology and Visual Science, Lions Eye Institute, University of Western Australia, Perth, Western Australia 6009, Australia.
¹⁵ Statistical Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia.
¹⁶ Sichuan Provincial Key Laboratory for Human Disease Gene Study, Hospital of the University of Electronic Science and Technology of China and Sichuan Provincial People's Hospital, Chengdu, Sichuan 610072, China.
¹⁷ School of Medicine, University of Electronic Science and Technology of China and Sichuan Provincial People's Hospital, Chengdu, Sichuan 610072, China.
¹⁸ Sichuan Translational Medicine Hospital, Chinese Academy of Sciences, Chengdu, Sichuan 610072, China.
¹⁹ Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Hong Kong SAR 99907, China.
²⁰ Centre for Myopia Research, School of Optometry, The Hong Kong Polytechnic University, Hong Kong SAR 99907, China.
²¹ Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University, Tokyo 1130034, Japan.
²² Singapore Eye Research Institute, Singapore National Eye Centre, Singapore 168751, Singapore.
²³ Department of Medicine, National University of Singapore and National University Health System, Singapore 119228, Singapore.
²⁴ Duke-NUS Graduate Medical School, Singapore 169857, Singapore.

PMID: 25823570
DOI: 10.1038/ncomms7689

Abstract

Myopia can cause severe visual impairment. Here, we report a two-stage genome-wide association study for three myopia-related traits in 9,804 Japanese individuals, which was extended with trans-ethnic replication in 2,674 Chinese and 2,690 Caucasian individuals. We identify WNT7B as a novel susceptibility gene for axial length (rs10453441, Pmeta=3.9 × 10(-13)) and corneal curvature (Pmeta=2.9 × 10(-40)) and confirm the previously reported association between GJD2 and myopia. WNT7B significantly associates with extreme myopia in a case-control study with 1,478 Asian patients and 4,689 controls (odds ratio (OR)meta=1.13, Pmeta=0.011). We also find in a mouse model of myopia downregulation of WNT7B expression in the cornea and upregulation in the retina, suggesting its possible role in the development of myopia.

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References

1. J Neurosci. 2001 Mar 1;21(5):RC132 - PubMed
1. Am J Hum Genet. 2013 Aug 8;93(2):264-77 - PubMed
1. Invest Ophthalmol Vis Sci. 2013 Jan 17;54(1):444-53 - PubMed
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Identification of myopia-associated WNT7B polymorphisms provides insights into the mechanism underlying the development of myopia

Collaborators

Affiliations

Identification of myopia-associated WNT7B polymorphisms provides insights into the mechanism underlying the development of myopia

Authors

Collaborators

Affiliations

Abstract

References

Publication types

MeSH terms

Substances

Grants and funding

LinkOut - more resources

Full Text Sources