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Comment
. 2015 Jun;11(6):325-7.
doi: 10.1038/nrendo.2015.53. Epub 2015 Mar 31.

Therapy: Lenvatinib and radioiodine-refractory thyroid cancers

Lara Dunn  1 , James A Fagin  1
Affiliations
Comment

Therapy: Lenvatinib and radioiodine-refractory thyroid cancers

Lara Dunn et al. Nat Rev Endocrinol. 2015 Jun.

Abstract

Over the past decade, several multikinase inhibitors have shown considerable effectiveness against metastatic radioiodine-refractory thyroid cancers in early stage clinical trials. On the basis of some remarkable results in a phase III clinical trial, lenvatinib now joins sorafenib as another multikinase inhibitor approved by the FDA for this disease.

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Comment on

  • Lenvatinib versus placebo in radioiodine-refractory thyroid cancer.
    Schlumberger M, Tahara M, Wirth LJ, Robinson B, Brose MS, Elisei R, Habra MA, Newbold K, Shah MH, Hoff AO, Gianoukakis AG, Kiyota N, Taylor MH, Kim SB, Krzyzanowska MK, Dutcus CE, de las Heras B, Zhu J, Sherman SI. Schlumberger M, et al. N Engl J Med. 2015 Feb 12;372(7):621-30. doi: 10.1056/NEJMoa1406470. N Engl J Med. 2015. PMID: 25671254 Clinical Trial.

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