Reply to Tzoulis et al.: Genetic and clinical heterogeneity of essential tremor

Affiliations

¹ Institute of Materials Science and Nanotechnology, National Nanotechnology Research Center (UNAM), and Departments of Medicine and of Genome Sciences, University of Washington, Seattle, WA 98195;
² Departments of Medicine and of Genome Sciences, University of Washington, Seattle, WA 98195;
³ Department of Neurology, Faculty of Medicine, Ankara University, Ankara 06100, Turkey;
⁴ Department of Molecular Biology and Genetics, Bilkent University, Ankara 06800, Turkey;
⁵ Department of Life Sciences, Bethlehem University, Bethlehem 92248, Palestinian Authority;
⁶ Department of Neurology, Faculty of Medicine, Mersin University, Mersin 33343, Turkey; and.
⁷ Department of Neurology and.
⁸ Department of Pediatrics, Neurology Unit, Faculty of Medicine, Hacettepe University, Ankara 06100, Turkey.
⁹ Departments of Medicine and of Genome Sciences, University of Washington, Seattle, WA 98195; mcking@u.washington.edu.
¹⁰ Institute of Materials Science and Nanotechnology, National Nanotechnology Research Center (UNAM), and Department of Molecular Biology and Genetics, Bilkent University, Ankara 06800, Turkey;
¹¹ Institute of Materials Science and Nanotechnology, National Nanotechnology Research Center (UNAM), and.

PMID: 25825780
PMCID: PMC4426455
DOI: 10.1073/pnas.1503756112

Comment

Reply to Tzoulis et al.: Genetic and clinical heterogeneity of essential tremor

Hilal Unal Gulsuner et al. Proc Natl Acad Sci U S A. 2015.

. 2015 May 5;112(18):E2269.

doi: 10.1073/pnas.1503756112. Epub 2015 Mar 30.

Authors

Affiliations

¹ Institute of Materials Science and Nanotechnology, National Nanotechnology Research Center (UNAM), and Departments of Medicine and of Genome Sciences, University of Washington, Seattle, WA 98195;
² Departments of Medicine and of Genome Sciences, University of Washington, Seattle, WA 98195;
³ Department of Neurology, Faculty of Medicine, Ankara University, Ankara 06100, Turkey;
⁴ Department of Molecular Biology and Genetics, Bilkent University, Ankara 06800, Turkey;
⁵ Department of Life Sciences, Bethlehem University, Bethlehem 92248, Palestinian Authority;
⁶ Department of Neurology, Faculty of Medicine, Mersin University, Mersin 33343, Turkey; and.
⁷ Department of Neurology and.
⁸ Department of Pediatrics, Neurology Unit, Faculty of Medicine, Hacettepe University, Ankara 06100, Turkey.
⁹ Departments of Medicine and of Genome Sciences, University of Washington, Seattle, WA 98195; mcking@u.washington.edu.
¹⁰ Institute of Materials Science and Nanotechnology, National Nanotechnology Research Center (UNAM), and Department of Molecular Biology and Genetics, Bilkent University, Ankara 06800, Turkey;
¹¹ Institute of Materials Science and Nanotechnology, National Nanotechnology Research Center (UNAM), and.

PMID: 25825780
PMCID: PMC4426455
DOI: 10.1073/pnas.1503756112

No abstract available

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Conflict of interest statement

The authors declare no conflict of interest.

Comment on

Mitochondrial serine protease HTRA2 p.G399S in a kindred with essential tremor and Parkinson disease.
Unal Gulsuner H, Gulsuner S, Mercan FN, Onat OE, Walsh T, Shahin H, Lee MK, Dogu O, Kansu T, Topaloglu H, Elibol B, Akbostanci C, King MC, Ozcelik T, Tekinay AB. Unal Gulsuner H, et al. Proc Natl Acad Sci U S A. 2014 Dec 23;111(51):18285-90. doi: 10.1073/pnas.1419581111. Epub 2014 Nov 24. Proc Natl Acad Sci U S A. 2014. PMID: 25422467 Free PMC article.
HTRA2 p.G399S in Parkinson disease, essential tremor, and tremulous cervical dystonia.
Tzoulis C, Zayats T, Knappskog PM, Müller B, Larsen JP, Tysnes OB, Bindoff LA, Johansson S, Haugarvoll K. Tzoulis C, et al. Proc Natl Acad Sci U S A. 2015 May 5;112(18):E2268. doi: 10.1073/pnas.1503105112. Epub 2015 Mar 30. Proc Natl Acad Sci U S A. 2015. PMID: 25825781 Free PMC article. No abstract available.

References

1. Unal Gulsuner H, et al. Mitochondrial serine protease HTRA2 p.G399S in a kindred with essential tremor and Parkinson disease. Proc Natl Acad Sci USA. 2014;111(51):18285–18290. - PMC - PubMed
1. Tzoulis C, et al. HTRA2 p.G399S in Parkinson disease, essential tremor, and tremulous cervical dystonia. Proc Natl Acad Sci USA. 2015;112:E2268. - PMC - PubMed
1. Louis ED. “Essential tremor” or “the essential tremors”: Is this one disease or a family of diseases? Neuroepidemiology. 2014;42(2):81–89. - PMC - PubMed
1. Jiménez-Jiménez FJ, et al. Update on genetics of essential tremor. Acta Neurol Scand. 2013;128(6):359–371. - PubMed
1. McClellan J, King M-C. Genetic heterogeneity in human disease. Cell. 2010;141(2):210–217. - PubMed

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Reply to Tzoulis et al.: Genetic and clinical heterogeneity of essential tremor

Affiliations

Reply to Tzoulis et al.: Genetic and clinical heterogeneity of essential tremor

Authors

Affiliations

Conflict of interest statement

Comment on

References

Publication types

MeSH terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical